Bisoprolol fumarate.
2.5 mg, 5 mg, and 10 mg.
B-Cor 2.5: 3 x 10 film-coated caplets, B-Cor 5: 2 x 15 film-coated tablets, B-Cor 10: 3 x 10 film-coated tablets.
Swallow whole with some liquid.
In the morning, on an empty stomach or with breakfast.
1 tablet of B-Cor 5 once daily.
Yes, it can be increased to 20 mg (2 tablets of B-Cor 10 once daily) if necessary.
High blood pressure (hypertension) and coronary heart disease (angina pectoris).
Untreated myocardial insufficiency (decompensated heart failure), recent myocardial infarction, shock, disturbances of atrioventricular conduction (AV block grades II and III), sick sinus syndrome, disturbed stimulus conduction between the sinoatrial node and atrium (sinoatrial block), extremely slow pulse (bradycardia with less than 50 beats/min) prior to the start of treatment, extremely low blood pressure (hypotension), bronchial asthma and advanced stages of peripheral circulatory disturbances.
No, it should not be used during pregnancy or lactation.
No, it should not be used in children.
B-Cor can potentiate the effects of other antihypertensive drugs, including reserpine, methyldopa, clonidine, guanfacine, and nifedipine. It can also interact with calcium antagonists (verapamil, diltiazem), antiarrhythmic agents, rifampicin, insulin, and oral antihyperglycaemic agents.
Tiredness, dizziness, mild headaches, perspiration, sleep disturbances, vivid dreams, depressive moods, gastrointestinal disturbances (diarrhoea, constipation, nausea, abdominal pain), skin reactions (e.g. erythema, pruritus), decreased blood pressure, slow pulse rate, disturbance of AV conduction, tingling and coldness in the limbs, muscle weakness, muscle cramp, reduced lacrimation, aggravation of intermittent claudication and Raynaud's phenomenon, intensification of myocardial insufficiency, increased airway resistance, impaired glucose tolerance in elderly patients with diabetes, masking of hypoglycemic symptoms, and potential impairment of driving and operating machinery.
Caution is warranted in diabetic patients with greatly fluctuating blood-glucose values, during prolonged periods of fasting and in patients with acidosis.
The anaesthetist should be informed that the patient is being treated with Bisoprolol, as cardiac output may be impaired under anaesthesia.
Therapy should not be discontinued abruptly but must be discontinued on a gradual basis.
Store below 30°C.
Afrab-Chem Ltd.
The drug should not be used once the expiry date has elapsed.