Co-Diovan 160 mg/25 mg tabl. #28

What is Co-Diovan used for?

Co-Diovan is used to treat high blood pressure (hypertension) in adults.

What are the active ingredients in Co-Diovan?

Valsartan and hydrochlorothiazide.

How does Co-Diovan work?

Valsartan blocks the effects of angiotensin II, a hormone that causes blood vessels to narrow. Hydrochlorothiazide reduces fluid in the body, which also helps lower blood pressure.

How often should I take Co-Diovan?

One coated tablet per day.

What is the maximum daily dose of Co-Diovan?

320 mg/25 mg.

What are the most common side effects of Co-Diovan?

Fatigue, orthostatic hypotension, mild nausea, vomiting, urticaria, rash, cough, and headache.

Are there any serious side effects associated with Co-Diovan?

Yes, including angioedema, acute renal failure, and non-melanoma skin cancer.

What are some potential drug interactions with Co-Diovan?

Potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium Non-steroidal anti-inflammatory drugs (NSAIDs) Lithium Other anti-hypertensive drugs Skeletal muscle relaxants Antidiabetic agents Digitalis glycosides Anticholinergic agents Ion exchange resins Vitamin D Ciclosporin Calcium salts Diazoxide Methyldopa Alcohol, barbiturates, and narcotics Pressor amines

What are the dosage recommendations for patients with renal impairment?

No adjustment is required for mild to moderate renal impairment (GFR ≥ 30 ml/min). Use with caution in patients with severe renal impairment (GFR < 30 ml/min).

What are the dosage recommendations for patients with hepatic impairment?

No adjustment is required for mild to moderate hepatic impairment. Use with caution in patients with severe hepatic impairment and biliary obstructive disorders.

Is Co-Diovan safe for use during pregnancy?

No, it is contraindicated.

Is Co-Diovan safe for use during breastfeeding?

No, it is not recommended.

Is Co-Diovan safe for use in children?

The safety and efficacy have not been established in children under 18 years old.

Who should not take Co-Diovan?

Patients with known hypersensitivity to valsartan, hydrochlorothiazide, other sulphonamide-derived medicinal products, or any of the excipients of Co-Diovan Anuria (no urine production) Concomitant use of angiotensin receptor antagonists (ARBs) - including valsartan- or of angiotensin-converting enzyme inhibitors (ACEIs) with aliskiren in patients with Type 2 diabetes

What are some important warnings and precautions associated with Co-Diovan?

Sodium and/or volume depletion Renal artery stenosis Severe renal impairment Severe hepatic impairment Biliary obstructive disorders Systemic lupus erythematosus Hypercalcemia Heart failure/post-myocardial infarction

What should I do if I miss a dose of Co-Diovan?

Take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose.

What should I do if I overdose on Co-Diovan?

Contact your doctor or local poison control center immediately.