Norvasc 10 mg tabl. #30

What is the active ingredient in Norvasc 10mg tablets?

amlodipine besylate, equivalent to 10mg of amlodipine.

What is Norvasc used for?

Hypertension, Coronary Artery Disease (CAD), Chronic Stable Angina

How does Norvasc work?

It is a calcium channel blocker that relaxes and widens blood vessels.

What are the contraindications for Norvasc?

Known hypersensitivity to dihydropyridines or any of the inactive ingredients.

Is it safe to use Norvasc in patients with renal failure?

Yes, at normal doses. Amlodipine is not dialyzable.

Is it safe to use Norvasc in patients with impaired hepatic function?

Administer with caution. Dosage recommendations have not been established.

What are some common side effects of Norvasc?

Headaches, dizziness, somnolence, palpitations, flushing, abdominal pain, nausea, edema, fatigue.

What are some less common side effects of Norvasc?

Leukopenia, thrombocytopenia, hyperglycemia, insomnia, mood altered, hypertonia, hypoesthesia, paraesthesia, neuropathy, peripheral, syncope, dysgeusia, tremor, extrapyramidal disorder, visual impairment, tinnitus, hypotension, vasculitis, cough, dyspnea, rhinitis, change in bowel habits, dry mouth, dyspepsia, gingival hyperplasia, pancreatitis, vomiting, alopecia, hyperhidrosis, discolouration, urticaria, arthralgia, back pain, muscle spasms, myalgia, pollakiuria, micturition disorder, nocturia, gynecomastia, erectile dysfunction, asthenia, malaise, pain, weight increased/decreased.

What are the potential interactions of Norvasc with other medications?

Strong CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir), clarithromycin, CYP3A4 inducers (rifampicin, hypericum perforatum), simvastatin, grapefruit juice, mTOR inhibitors (sirolimus, temsirolimus, everolimus).

Is it safe to use Norvasc during pregnancy and lactation?

Safety has not been established. It is only recommended if there is no safer alternative. Amlodipine is transferred into human breast milk.

What should I do if I take too much Norvasc?

Seek immediate medical attention.

What is the usual starting dose of Norvasc?

5mg once daily.

How should I store Norvasc?

Below 30°C (86°F) and out of reach of children.

What are the key findings of the CAMELOT trial?

Amlodipine reduced revascularization procedures, hospitalizations for angina, and the composite cardiovascular endpoint in patients with CAD.

What are the key findings of the ALLHAT trial?

Amlodipine-based therapy was not significantly different from chlorthalidone-based therapy in terms of fatal CHD or non-fatal MI, the primary endpoint. No significant difference in all-cause mortality between the two groups.

What are the key findings of the PRAISE-2 trial?

Amlodipine did not increase the risk of mortality or combined mortality and morbidity in patients with heart failure. Increased reports of pulmonary edema.

What are the key findings of the PREVENT trial?

Amlodipine arrested the progression of carotid intima-media thickening and reduced the combined endpoint of cardiovascular death, MI, stroke, PTCA, coronary artery bypass graft, hospitalization for unstable angina, and worsening congestive heart failure.

What is the recommended dosage of Norvasc for children?

2.5mg to 5mg once daily for children aged 6 to 17 years. Doses in excess of 5mg daily have not been studied.

Are there any known drug/laboratory test interactions with Norvasc?

None known.

Where can I get more information about Norvasc?

Consult your doctor, pharmacist, or visit the official website of the manufacturer.