Augmentin 375 tabl. #20

What is the dosage of Augmentin 375 for adults and children over 12 for mild to moderate infections?

One 375mg tablet every 8 hours.

What is the dosage of Augmentin 375 for adults and children over 12 for severe infections?

Two 375mg tablets every 8 hours OR one 625mg tablet every 8 hours.

How should Augmentin be taken to minimize gastrointestinal issues?

At the start of a meal.

What are the contraindications for Augmentin?

A history of hypersensitivity to beta-lactams (e.g., penicillins and cephalosporins) or a previous history of Augmentin-associated jaundice/hepatic dysfunction.

What should be done if an allergic reaction occurs while taking Augmentin?

Augmentin therapy must be discontinued immediately, and appropriate alternative therapy should be started. Serious anaphylactic reactions require immediate emergency treatment.

What is the recommended dosage adjustment for patients with renal impairment and CrCl 10-30 mL/min?

The usual dose of Augmentin 375mg OR 625mg every 12 hours.

What is the recommended dosage adjustment for patients with renal impairment and CrCl <10 mL/min?

The usual dose of Augmentin 375mg OR 625mg every 24 hours.

What is the recommended dosage adjustment for patients on hemodialysis?

The usual dose of Augmentin 375mg OR 625mg every 24 hours, plus an additional dose during dialysis and another at the end of dialysis.

What are some common adverse reactions associated with Augmentin?

Diarrhea, nausea, and vomiting are very common. Skin rash, pruritus, and urticaria are also common.

What is the interaction between Augmentin and oral anticoagulants?

Abnormal prolongation of prothrombin time (increased INR) has been reported rarely. Appropriate monitoring should be undertaken and dosage adjustments of oral anticoagulants may be necessary.

Can Augmentin be used during pregnancy and lactation?

Augmentin should be avoided in pregnancy, especially during the first trimester, unless considered essential. Augmentin may be administered during lactation.

What is the relationship between Augmentin and infectious mononucleosis?

Augmentin should be avoided if infectious mononucleosis is suspected.

How should Augmentin suspension be stored after reconstitution?

It must be stored in a refrigerator (2°C to 8°C) and used within 7 days. Do not freeze.

Does Augmentin contain potassium?

Yes, each Augmentin 375 mg tablet contains 25 mg of potassium (0.63 mmol).

What is pseudomembranous colitis, and how does it relate to Augmentin?

Pseudomembranous colitis is inflammation of the colon often caused by Clostridium difficile infection. It can be a serious side effect of antibiotic use.

What is the maximum duration of treatment with Augmentin without review?

Treatment should not be extended beyond 14 days without review by a physician.