Aday Kit tabl. #4

What are the three active ingredients in Aday Kit and their respective strengths?

Secnidazole: 1 gm
Azithromycin Dihydrate: 1 gm (equivalent to Anhydrous Azithromycin)
Fluconazole: 150 mg

What is the dosage form of the Aday Kit tablets?

Film-coated and uncoated tablets.

What are the therapeutic indications for each active ingredient in Aday Kit?

Secnidazole: Amoebiasis, giardiasis, trichomoniasis, urethritis, and vaginitis.
Azithromycin: Otitis media, tonsillitis, laryngitis, bronchitis, pneumonia, sinusitis, non-gonococcal urethritis and cervicitis.
Fluconazole: Fungal infections.

What is the recommended dosage and method of administration for each active ingredient?

Secnidazole: 2 tablets as a single dose with food.
Azithromycin: 1 tablet as a single dose at least 1 hour before or 2 hours after a meal.
Fluconazole: 1 tablet as a single dose, either with secnidazole or alone.
Method of Administration: Oral use.

Are there any contraindications for the use of Aday Kit?

Secnidazole: Pregnancy, lactation, and hypersensitivity.
Azithromycin: Hepatic impairment and hypersensitivity.
Fluconazole: Hypersensitivity.

What are some special warnings and precautions for use associated with each active ingredient?

Secnidazole: Avoid alcohol during treatment. Not for individuals with blood dyscrasia.
Azithromycin: Use with caution in patients with illness, allergies, liver disease, jaundice, history of colitis or stomach problems, or kidney disease. Use only if clearly needed during pregnancy or lactation.
Fluconazole: Use with caution in patients with liver disease, kidney disease, or any drug allergy. Use only when clearly needed during pregnancy. Avoid during lactation.

What are some known drug interactions associated with each active ingredient?

Secnidazole: May potentiate the anticoagulant effect of warfarin. Antabuse-like effects with disulfiram. Cimetidine prolongs its half-life.
Azithromycin: Interacts with aluminum hydroxide and oxide, astemizole, cyclosporine A, digoxin, terfenadine, theophylline, and triazolam.
Fluconazole: Interacts with a large number of drugs, including alfentanil, Aliskiren, Alprazolam, Amitriptyline, Artesunate, astemizole, bosentan, celecoxib, chlorpropamide, cisapride, cyclosporine A, fosphenytoin, hydrochlorthiazide, loratadine, losartan, nortriptyline, phenytoin, Quetiapine, Repaglindine, rifabutin, rifampicin, ritonavir, sacchromyces, silfapyridine, silphamethaxazole, terfenadine, theophylline, torasemide, warfarin, and zidovudine.

What are the recommendations for use of Aday Kit during pregnancy and lactation?

Secnidazole: May be prescribed after the first trimester of pregnancy. Not recommended during the first trimester or lactation.
Azithromycin: Caution is advised during pregnancy and lactation. Classified as Category B.
Fluconazole: No adequate studies in pregnant women. Generally not recommended during pregnancy. Not recommended during lactation.

What are the possible undesirable effects associated with Aday Kit?

None are listed in the provided text.

What are the instructions for overdose and treatment of Aday Kit?

Symptomatic treatment should be instituted. Supportive measures and gastric lavage may be indicated.

What are the pharmacodynamic properties of each active ingredient in Aday Kit?

Secnidazole: Anti-amoebic activity against Entamoeba histolytica and Giardia lamblia.
Azithromycin: Binds to the 50S ribosomal subunit, inhibiting protein synthesis.
Fluconazole: Inhibits fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation, affecting ergosterol biosynthesis.

What are the pharmacokinetic properties of each active ingredient in Aday Kit?

Fluconazole: Rapidly and almost completely absorbed from the GI tract. Bioavailability exceeds 90%. Peak plasma concentrations achieved within 1-2 hours.
Azithromycin: Unique pharmacokinetic properties with high and prolonged tissue and phagocyte concentrations.
Secnidazole: Bioavailability approaches 90-100%. Peak serum levels between 9 and 13 mg after a single 500mg oral dose.

What are the inactive ingredients (excipients) in Aday Kit?

Secnidazole Tablet Excipients: Maize starch, Dibasic Calcium Phosphate, Colloidal Anhydrous silica, Cross carmellose sodium, Purified Talc, Magnesium Stearate, Opadry 03 F580020/Insta Coat Sol IC-S010, Iso Propyl Alcohol, Dichloromethane
Azithromycin Tablet Excipients: Cross carmellose sodium, Maize starch, Sodium Lauryl Sulphate, Povidone K30, Colloidal silicon dioxide, Magnesium Stearate, Stearic acid, Ponceau 4R lake, Macrogol, Hypromellose, Titanium dioxide
Fluconazole Tablet Excipients: Sodium lauryl sulphate, Lactose Monohydrate, Maize starch, Cross carmellose sodium, Ponceau 4R lake, Povidone k-30, Iso propyl alcohol, Dichloromethane, Colloidal silicon dioxide, Magnesium stearate, Sodium starch glycolate (Type A)

What is the shelf life of Aday Kit?

24 months

What are the special precautions for storage of Aday Kit?

Store below 30°C and protect from light and moisture.

What is the packaging of Aday Kit?

20 x 1 x 4's tablets packed in Aluminum/PVDC coated PVC film Blister pack in a carton with a pack insert.

What are the special precautions for disposal of Aday Kit?

No special requirements.