Klovinal suppositories vaginal #6

What is the composition of Klovinal Pessary?

Each pessary contains 500 mg Metronidazole BP, 100 mg Clotrimazole BP, 150 million Lactobacillus Spores, and other excipients.

What is the mechanism of action of Clotrimazole?

Clotrimazole is a broad-spectrum antifungal agent that alters the permeability of fungal cell walls by interfering with cell wall lipids. It is effective against yeast, dermatophytes, and some Gram-positive bacteria like Staphylococci.

What is the mechanism of action of Metronidazole?

Metronidazole is active against several protozoa, including Trichomonas vaginalis. It is bactericidal and used to treat susceptible protozoal infections and anaerobic infections, including bacterial vaginosis.

Why are Lactobacillus spores included in Klovinal Pessary?

Lactobacillus spores are used to recolonize the vaginal flora and maintain a healthy vaginal pH between 3.8 and 4.2. This helps to prevent the overgrowth of pathogenic bacteria.

What is the role of Lactobacillus in maintaining a healthy vaginal ecosystem?

Lactobacilli are the dominant bacteria in a healthy vagina. They produce lactic acid and other organic acids, keeping the vaginal pH acidic. This environment inhibits the growth of harmful bacteria and other pathogens.

How does Klovinal Pessary treat vaginal infections like trichomoniasis, bacterial vaginosis, and vulvovaginal candidiasis?

Klovinal Pessary addresses different aspects of these infections: * **Metronidazole:** Treats trichomoniasis and bacterial vaginosis. * **Clotrimazole:** Treats vulvovaginal candidiasis. * **Lactobacillus:** Recolonizes the vaginal flora and restores a healthy vaginal pH, preventing recurrence of infections.

What are the potential adverse reactions associated with Klovinal Pessary?

Some patients may experience local pruritis and burning sensation after vaginal administration.

What should be done if irritation or sensitivity develop during treatment with Klovinal Pessary?

Treatment should be discontinued immediately and appropriate therapy instituted.

What should be done if there is no response to Klovinal Pessary treatment?

Microbiological studies should be conducted to confirm the diagnosis and rule out other pathogens before initiating alternative antifungal therapy.

How is Klovinal Pessary administered?

One pessary should be inserted into the vagina as deeply as possible once daily for 6 days, preferably at bedtime.

Should Klovinal Pessary be used during menstruation?

Treatment should not be carried out during menstruation.

What interactions should be considered when using Klovinal Pessary?

Antibiotics with activity against lactobacilli should be avoided.

Is Klovinal Pessary safe for use during pregnancy and lactation?

Klovinal Pessary should only be given to pregnant or lactating mothers if the benefits outweigh the possible risks to the fetus.

How should Klovinal Pessary be stored?

Keep in a dry place, below 30°C, protected from light. Keep out of reach and sight of children.

What are the instructions for using Klovinal Pessaries?

1. Wash your hands. 2. If the pessary feels soft, hold it under cold water or place it in the refrigerator for a few minutes to harden it. 3. Remove one pessary from the strip and hold it in your fingertips. 4. Remove any foil or plastic wrapping stuck to the pessary. 5. Sit or lie down with your knees bent and legs apart. 6. Gently insert the pessary into the vagina as far as comfortably possible using your fingers. 7. Wash your hands again.

**Please note:** This information is for general knowledge and not a substitute for professional medical advice. Consult with a healthcare professional before using Klovinal Pessary or any medication.