Amatem 20 mg/120 mg softgels #18

What is Amatem 20/120 Softgel and what are its components?

Amatem 20/120 Softgel is an artemisinin-based combination therapy (ACT) antimalarial medication containing 20mg of Artemether and 120mg of Lumefantrine.

How does Amatem 20/120 work against malaria?

Amatem combines Artemether and Lumefantrine, which have different mechanisms of action, providing a dual attack against malaria parasites.

How is Amatem 20/120 absorbed and eliminated by the body?

Artemether is absorbed quickly (peak concentration at 2 hours), while Lumefantrine absorbs slower (peak at 6-8 hours). Both bind to plasma proteins. Artemether is eliminated quickly (half-life ~2 hours), while Lumefantrine has a longer half-life (3-6 days).

What is the recommended dosage of Amatem 20/120 for adults and children?

Dosage depends on body weight, administered over 3 days (6 doses): 15 kg to <25 kg: 12 capsules total; 25 kg to <35 kg: 18 capsules total; 35 kg and above: 24 capsules total. Specific dosing instructions are provided within the initial dose and subsequent doses over the three day period.

What conditions should be considered before taking Amatem 20/120?

Contraindicated in individuals with hypersensitivity to its ingredients, those taking medications metabolized by CYP2D6, or with electrolyte imbalances. Caution during pregnancy and breastfeeding. Not evaluated for severe malaria.

Can Amatem 20/120 be taken during pregnancy or while breastfeeding?

Not recommended during the first trimester. Second/third trimester use only if benefits outweigh risks. Breastfeeding should be stopped during treatment and for at least one week after.

What are the potential drug interactions with Amatem 20/120?

May interact with other antimalarials, CYP450 3A4 inhibitors, protease inhibitors, and antiretroviral drugs.

What should be done in case of an Amatem 20/120 overdose?

Seek immediate medical attention.

What is the proper storage for Amatem 20/120 Softgels?

Below 25°C in a cool, dry place, protected from light.

What are the available pack sizes for Amatem 20/120 Softgels?

Available in blister packs of 12, 18, and 24 capsules. Patients must be able to swallow the capsules.