Amatem Forte 80 mg/480 mg softgels #6

What is the composition of each Amatem Forte softgel?

Each Amatem Forte softgel contains 80 mg of Artemether and 480 mg of Lumefantrine, along with excipients and approved colorants.

How should Amatem Forte be taken by adults?

Adults weighing 35 kg and above should take one capsule initially, another after 8 hours, and then one capsule twice daily (morning and evening) for the next two days (total 6 capsules over 3 days).

What is the mechanism of action of Amatem Forte?

It's an artemisinin-based combination therapy (ACT) where artemether and lumefantrine work together to eliminate malaria parasites.

Are there any contraindications for Amatem Forte?

Yes, hypersensitivity to ingredients, concomitant use of CYP2D6-metabolized drugs, and electrolyte imbalances like hypokalemia.

What are the special precautions and warnings associated with Amatem Forte?

Avoid use in the first trimester of pregnancy, and use with caution in the second and third trimesters. Not evaluated for severe malaria.

What are the pharmacokinetics of Artemether and Lumefantrine?

Artemether is absorbed quickly (peak at 2 hours), lumefantrine more slowly (peak at 6-8 hours). Both are highly protein-bound. Artemether has a short half-life (2 hours), while lumefantrine's is longer (3-6 days).

What should be done in case of an overdose?

Symptomatic and supportive therapy, including ECG and blood potassium monitoring.

How should Amatem Forte be stored?

Below 25°C in a cool and dry place.

What are the known drug interactions with Amatem Forte?

Other antimalarials, CYP450 3A4 inhibitors, protease inhibitors, and antiretroviral drugs.

What are the recommendations regarding Amatem Forte use during pregnancy and lactation?

Avoid in the first trimester. Use with caution in the second and third if benefits outweigh risks. Avoid breastfeeding during and for one week after treatment.

What is Amatem Forte indicated for?

Treatment of most forms of malaria, including resistant types.

What is the presentation of Amatem Forte 80mg/480mg #6?

Blister packs of six soft gelatin capsules.