Amatem Forte 80 mg/480 mg tabl. #6

What is Amatem Forte and what is it used for?

Amatem Forte is a combination antimalarial medication containing 80mg of Artemether and 480mg of Lumefantrine used to treat acute uncomplicated Plasmodium falciparum malaria in adults and children weighing 35kg or more.

How does Amatem Forte work against malaria?

Artemether and Lumefantrine target the malaria parasite's food vacuole, interfering with heme conversion. Lumefantrine disrupts heme polymerization, while Artemether creates reactive metabolites that interact with heme iron. They also inhibit nucleic acid and protein synthesis within the parasite.

What is the recommended dosage of Amatem Forte?

Six tablets over three days, taken orally with food: Day 1: one tablet at 0 and 8 hours; Day 2: one tablet at 24 and 36 hours; Day 3: one tablet at 48 and 60 hours.

Are there any contraindications for Amatem Forte?

Yes. Hypersensitivity to ingredients, severe malaria, use of CYP2D6 metabolized drugs, family history of sudden death or long QTc interval, use of QTc prolonging drugs, history of cardiac arrhythmias, bradycardia, or congestive heart failure with reduced ejection fraction.

What are the potential side effects of Amatem Forte?

Common: decreased appetite, sleep disorders, headache, dizziness, cough, vomiting, abdominal pain, nausea, and diarrhea. Less common side effects are also possible.

Are there any drug interactions with Amatem Forte?

Do not take with QTc prolonging drugs or CYP2D6 metabolized drugs. Not recommended with other antimalarials unless necessary. Caution with CYP3A4 inhibitors.

Can pregnant or breastfeeding women take Amatem Forte?

Not recommended during the first trimester unless life-threatening. Second and third trimesters only if benefit outweighs risk. Breastfeeding should be avoided during treatment and for one week after.

What should I do if I miss a dose or vomit after taking Amatem Forte?

Contact your doctor or pharmacist immediately.

How should Amatem Forte be stored?

Dry place below 30°C (86°F), protected from light, and out of reach of children.

How is Amatem Forte metabolized and eliminated from the body?

Artemether is rapidly metabolized by the liver (CYP3A4/5) to dihydroartemisinin. Both have a short half-life (≈2 hours). Lumefantrine is metabolized more slowly (CYP3A4) with a longer half-life (2-6 days). Excretion is primarily through feces.