Havax Forte 80 mg/480 mg tabl. #6

What is Havax Forte indicated for?

Havax Forte is indicated for the treatment of acute uncomplicated Plasmodium falciparum malaria in adults, children, and infants weighing 5 kg and above.

What is the dosage regimen for Havax Forte?

Two tablets twice a day (morning and evening) for three days with a high-fat meal or fatty drink. A total of 12 tablets over three days. Repeat dose if vomiting occurs within 1 hour.

What are the contraindications for Havax Forte?

Hypersensitivity to components, severe malaria, drugs metabolized by CYP2D6, family history of sudden death or prolonged QTc interval, drugs that prolong the QTc interval, history of cardiac arrhythmias, bradycardia, or congestive heart failure, electrolyte imbalances, and strong CYP3A4 inducers.

What are the precautions for using Havax Forte?

Caution with hormonal contraceptives and drugs that interact with CYP3A4. Also, caution in patients with severe hepatic impairment.

What are the known drug interactions with Havax Forte?

Drugs that prolong the QTc interval, drugs metabolized by CYP2D6, strong CYP3A4 inducers, hormonal contraceptives, and drugs that inhibit, moderately induce, or compete for CYP3A4.

What are the adverse reactions associated with Havax Forte?

Headache, dizziness, decreased appetite, palpitations, vomiting, abdominal pain, nausea, arthralgia, and fatigue.

What are the components and their strengths in Havax Forte tablets?

80 mg of artemether and 480 mg of lumefantrine.

What is the mechanism of action of Havax Forte?

Artemether and lumefantrine interfere with heme conversion to hemozoin within the malarial parasite. They also inhibit nucleic acid and protein synthesis.

What should be done in case of an overdose of Havax Forte?

Symptomatic and supportive therapy, including ECG and blood potassium monitoring.

What are the recommendations for Havax Forte use during pregnancy and lactation?

Not recommended, especially during the first trimester of pregnancy and during lactation.

How is Havax Forte metabolized and eliminated?

Artemether is rapidly metabolized by CYP3A4/5 to dihydroartemisinin. Both have a short half-life (around 2 hours). Lumefantrine is eliminated more slowly, with a half-life of 2 to 6 days.