Havax Forte softgels #6

What is the composition of Havax Forte softgels?

Each Havax Forte softgel contains 80mg of Artemether and 480mg of Lumefantrine, along with excipients and approved colors used in the capsule shell.

How should Havax Forte be stored?

Store Havax Forte below 30°C in a cool, dry, and dark place. Protect from light and keep out of reach of children.

What is the dosage regimen for Havax Forte in adults?

Adults (16 years and above) weighing 35kg and above should take a total of 6 capsules over 3 days: one initially, another after 8 hours, and then one capsule twice daily (morning and evening) for the next two days.

What are the indications for using Havax Forte?

Havax Forte is indicated for the treatment of most forms of malaria, including resistant types.

What is the mechanism of action of Havax Forte?

Havax Forte is an artemisinin-based combination therapy (ACT) combining artemether and lumefantrine.

What are the contraindications for Havax Forte?

Havax Forte is contraindicated in individuals with hypersensitivity to any of its ingredients, those taking drugs metabolized by CYP2D6 (e.g., flecainide, metoprolol, imipramine, amitriptyline, clomipramine), and patients with electrolyte imbalances like hypokalemia.

What are the special precautions and warnings associated with Havax Forte use?

Havax Forte should not be used during the first trimester of pregnancy and its safety and efficacy haven't been established for the treatment of severe malaria.

What are the pharmacokinetics of Artemether and Lumefantrine?

Artemether is absorbed quickly, reaching peak plasma concentrations in about 2 hours, with an elimination half-life of about 2 hours. Lumefantrine absorption begins after a lag time of up to 2 hours, reaching peak plasma concentrations in 6-8 hours, with a longer elimination half-life of 3-6 days. Both are highly bound to human serum proteins.

What should be done in case of a suspected Havax Forte overdose?

Symptomatic and supportive therapy should be administered, including ECG and blood potassium monitoring.

Can Havax Forte be used during pregnancy and lactation?

There is insufficient data on Havax Forte use during pregnancy. Animal data suggest potential serious birth defects in the first trimester. In the second and third trimesters, it should only be considered if the benefits outweigh the risks. Women taking Havax Forte should not breastfeed during treatment and for at least one week after the last dose, unless the potential benefits outweigh the risks.

Are there any known drug interactions with Havax Forte?

Havax Forte can interact with other antimalarials, CYP450 3A4 inhibitors, protease inhibitors, and antiretroviral drugs.

Who manufactures Havax Forte?

Havax Forte is manufactured by Briyosis Soft Caps Pvt. Ltd., India, and distributed by Embassy Pharmaceuticals and Chem. Ltd., Lagos, Nigeria.

What is the presentation of Havax Forte?

Havax Forte is available in blister packs of 6 soft gelatin capsules.

Is there a specific warning regarding the administration of Havax Forte to children?

Yes, Havax Forte should only be given to children who can swallow the soft gelatin capsules. No dosage information is provided for children under 35kg or under 16 years old.