Havax softgels #24

Q: What is the dosage of Havax Softgels #24 for adults and children weighing 35kg and above?

Four capsules as a single dose initially, another four capsules after eight hours, then four capsules twice daily (morning and evening) for two days (total 24 capsules over three days). Take with a high-fat meal/drink.

Q: What are the indications for using Havax Softgels?

Treatment of most forms of malaria, including resistant types.

Q: What is the mechanism of action of Havax Softgels?

Artemether and lumefantrine (artemisinin-based combination therapy) work together to eliminate the malaria parasite.

Q: Are there any contraindications for using Havax Softgels?

Yes. Hypersensitivity to ingredients, patients taking drugs metabolized by CYP2D6, and patients with electrolyte imbalances.

Q: What are the special precautions and warnings associated with Havax Softgel use?

Not for use in the first trimester of pregnancy, effectiveness in severe malaria not evaluated, encourage normal eating, repeat dose if vomiting within one hour.

Q: What should be done in case of an overdose of Havax Softgels?

Symptomatic and supportive therapy, including ECG and blood potassium monitoring.

Q: How should Havax Softgels be stored?

Below 30°C in a cool, dry, and dark place. Protect from light. Keep out of reach of children.

Q: What are the pharmacokinetics of artemether and lumefantrine?

Artemether: rapid absorption, peak concentration at 2 hours, half-life ~2 hours. Lumefantrine: absorption after a lag time of up to 2 hours, peak concentration at 6-8 hours, half-life 3-6 days. Both are highly protein-bound.

Q: Can Havax Softgels be used during pregnancy and breastfeeding?

Pregnancy: Not in first trimester; second/third trimester only if benefit outweighs risk. Breastfeeding: Not recommended during treatment and for at least one week after, unless benefit outweighs risk.

Q: What are the known drug interactions with Havax Softgels?

Other antimalarials, CYP450 3A4 inhibitors, protease inhibitors, and antiretroviral drugs. Consult a healthcare professional.

Q: What is the presentation of Havax Softgels?

Blister packs of 12, 18, and 24 soft gelatin capsules. #24 pack is one full adult treatment course.

Q: What is the composition of each Havax Softgel capsule?

20mg Artemether and 120mg Lumefantrine, plus excipients and approved colours.