Lonart 20 mg/120 mg tabl. #24

What is the composition of Lonart 20mg/120mg tablets?

Each tablet contains 20mg of Artemether and 120mg of Lumefantrine, along with excipients.

What are the indications for using Lonart 20mg/120mg tablets?

Treatment of acute, uncomplicated malaria infections caused by Plasmodium falciparum.

How should Lonart be administered?

Orally with food or a milky drink. Repeat dose if vomiting occurs within 1 hour. If food cannot be tolerated, take with water, but absorption may be reduced.

What is the dosage regimen for Lonart 20mg/120mg tablets?

Refer to Figure 1 (not provided).

What are the contraindications for using Lonart?

Hypersensitivity to ingredients, family history of sudden death or congenital QT prolongation, history of QT prolongation, concurrent use of QT-prolonging drugs, cardiac arrhythmias, bradycardia, reduced left ventricle ejection fraction, electrolyte imbalances, use of strong CYP3A4 inducers, severe malaria complications, use of drugs metabolized by CYP2D6, and first trimester of pregnancy (when other options are available).

What are the warnings and precautions associated with Lonart use?

Avoid in first trimester if possible; caution in second and third. Not for severe malaria. Monitor for deterioration. ECG and electrolyte monitoring if deterioration occurs. Consider lumefantrine's half-life. Caution with quinine, mefloquine, halofantrine, ARTs, renal/hepatic impairment. Monitor food intake if aversion persists. Potential for QT prolongation.

What are the common adverse effects of Lonart?

Decreased appetite, psychiatric and sleep disorders, headache, dizziness, paraesthesia, clonus, palpitations, prolonged QT interval, cough, vomiting, abdominal pain, nausea, diarrhea, increased liver function tests, rash, pruritus, arthralgia, myalgia, asthenia, fatigue, and gait disturbance.

What should be done in case of a Lonart overdose?

Symptomatic and supportive therapy, including ECG and blood potassium monitoring.

What are the drug interactions to be aware of with Lonart?

Caution with CYP3A4 inhibitors; contraindicated with QT prolonging drugs. May interact with ARTs, CYP2D6 substrates, hormonal contraceptives, and grapefruit juice. Avoid strong CYP3A4 inducers. Monitor with mefloquine and quinine.

How should Lonart be stored?

Dry place below 30°C, out of reach of children.