Lonart 20 mg/120 mg/5 ml powder for suspension bottle 60.0 ml #1

What is Lonart 20/120 used for?

Lonart 20/120 Oral Suspension is indicated for the treatment of malaria in children, including severe malaria caused by multiple drug-resistant strains of P. Falciparum.

What are the active ingredients in Lonart 20/120 and how much is in each dose?

Each 5 ml of reconstituted Lonart 20/120 oral suspension contains 20 mg of Artemether and 120 mg of Lumefantrine.

How should Lonart 20/120 be taken?

Dosage depends on the child's weight and is given twice daily (morning and night) for three days. See the dosage chart in the original text. It should be taken with fatty food or a drink.

How is Lonart 20/120 reconstituted?

Add boiled and cooled water to the 60ml mark, invert and shake vigorously. Add more water if needed to reach 60ml and shake again. Shake well before each use. Store in a refrigerator and use within 7 days.

What are the precautions and contraindications for Lonart 20/120?

Contraindicated in individuals hypersensitive to Artemether and/or Lumefantrine. Caution in patients taking drugs that prolong the QT interval or those predisposed to cardiac arrhythmias. Generally avoided during pregnancy/breastfeeding, but may be prescribed for severe malaria during pregnancy. Breastfeeding shouldn't resume until at least one week after treatment.

What are the potential side effects of Lonart 20/120?

Common side effects may include rash, trouble sleeping, nausea, vomiting, diarrhea, and coughing. Seek medical attention if these persist. Rare side effects include transient abdominal pain, tinnitus, and diarrhea.

How do Artemether and Lumefantrine work against malaria?

Artemether generates singlet oxygen and free radicals toxic to malaria parasites and causes morphological changes in parasitic membranes. Lumefantrine interferes with polymerization and affects nucleic acid and protein synthesis in the parasites.

Are there any known drug interactions with Lonart 20/120?

While specific negative interactions haven't been observed, Artemether may potentiate other antimalarials. Avoid grapefruit juice.

What is the shelf life of unreconstituted Lonart 20/120 and how should it be stored?

The shelf life of unreconstituted Lonart 20/120 is not explicitly stated. Store unreconstituted powder in a dry place below 30°C and protected from light. Reconstituted suspension should be used within 7 days.

Has resistance to Artemether been observed?

Resistance to Artemether has not been observed. Apparent resistance may occur due to multiple broods of plasmodia. In cases of recrudescence, a new three-day treatment is recommended.