Lonart-DS 80 mg/480 mg tabl. #6

What is the composition of each Lonart DS tablet?

Each tablet contains 80 mg of Artemether and 480 mg of Lumefantrine, along with excipients and coloring agents.

What are the indications for using Lonart DS?

Treatment of malaria, including multi-drug resistant strains of P. falciparum.

What is the recommended dosage regimen for Lonart DS?

Six tablets total for individuals 35 kg and above: one tablet at 0, 8, 24, 36, 48, and 60 hours. Take with food, especially a fatty meal.

Are there any drug interactions with Lonart DS?

No specific negative drug-drug interactions observed. Avoid grapefruit juice. Caution with drugs that prolong the QT interval.

What are the common side effects of Lonart DS?

Rash, trouble sleeping, nausea, vomiting, diarrhea, and coughing. Seek medical attention if these persist.

What are the contraindications for Lonart DS?

Hypersensitivity to Artemether or Lumefantrine. Caution in patients taking drugs that prolong the QT interval.

Can Lonart DS be used during pregnancy or breastfeeding?

Avoid during pregnancy unless essential. Do not use during breastfeeding and for at least one week after stopping treatment.

What is the mechanism of action of Lonart DS?

Artemether generates cytotoxic oxygen and free radicals. Lumefantrine interferes with polymerization. Both diminish nucleic acid and protein synthesis.

What are the pharmacokinetic properties of Lonart DS?

Artemether: rapidly absorbed, metabolized to DHA, half-life of 2-4 hours. Lumefantrine: absorption enhanced by fatty foods, metabolized to a more potent form, half-life of 4-6 days.

What should be done in case of recrudescence after Lonart DS treatment?

A new complete three-day treatment course is recommended.