P-Alaxin 120 mg/960 mg TS tabl. #3

What is the composition of P-Alaxin TS tablets?

Each tablet contains 120 mg of Dihydroartemisinin and 960 mg of Piperaquine Phosphate, along with excipients including Brilliant blue, Indigo carmine, and Titanium dioxide.

What are the indications for using P-Alaxin TS tablets?

Treatment of uncomplicated Plasmodium falciparum malaria.

How should P-Alaxin TS tablets be administered?

Orally with water on an empty stomach daily for 3 days. Dosage should be determined by a doctor based on the patient's weight.

What are the contraindications for P-Alaxin TS tablets?

Hypersensitivity to dihydroartemisinin, piperaquine phosphate, or any of the excipients. First trimester of pregnancy.

Are there any warnings or precautions associated with P-Alaxin TS tablets?

Caution with hepatic or renal impairment. Do not exceed the stated dosage.

What are the potential adverse reactions of P-Alaxin TS tablets?

Nausea, vomiting, reversible reduction in reticulocyte counts (dihydroartemisinin), mild dizziness, vertigo, headache, nausea, vomiting, abdominal discomfort, reversible leucopenia, dyspnea, and palpitations (piperaquine phosphate).

What are the pharmacokinetic properties of Dihydroartemisinin and Piperaquine Phosphate?

Dihydroartemisinin: Rapid absorption, peak concentration within 1 hour, half-life ~4 hours, widely distributed, ~80% excreted within 24 hours.Piperaquine Phosphate: 80-90% absorbed within 24 hours, widely distributed, slow elimination, half-life ~9.4 days, excreted in bile.

What are the drug interactions to be aware of with P-Alaxin TS tablets?

CYP3A4 inhibitors, CYP2C19 inhibitors, rifampicin, carbamazepine, phenytoin, and phenobarbital.

What should be done in case of an overdose?

Symptomatic and supportive therapy, ECG monitoring.

What are the recommendations regarding pregnancy and lactation?

Not recommended during pregnancy, especially the first trimester. Women taking P-Alaxin TS should not breastfeed.

How should P-Alaxin TS be stored?

Dry place below 30°C, protected from light, out of reach of children.

What is the presentation of P-Alaxin TS?

Blister packs of 3 tablets.

How does P-Alaxin TS work (pharmacodynamics)?

Dihydroartemisinin: Interferes with P. falciparum trophozoite membrane structures, disrupts protein and nucleic acid synthesis.Piperaquine Phosphate: Interferes with the trophozoite food vacuole membrane function.