Aceclofenac (100mg) and Paracetamol (500mg).
Aceclofenac inhibits the production of prostaglandins by blocking the enzyme cyclooxygenase.
Paracetamol is an analgesic and antipyretic (fever reducer), with weak anti-inflammatory effects. It works by raising the pain threshold and inhibiting COX in the brain.
Severe pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, low back pain, dental pain, gynecological pain, and painful/inflammatory conditions of the ear, nose, and throat.
It is categorized as a non-steroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic agent.
Orally.
1 tablet twice daily.
Generally, no dose adjustments are necessary in these cases.
Safety and efficacy have not been established in children.
In patients with: Sensitivity to aceclofenac, paracetamol, or any excipients of the product. History of aspirin or other NSAID-induced bronchospasm, rhinitis, or urticaria. Active or suspected peptic ulcer, gastrointestinal bleeding, or bleeding disorders. Severe heart failure, hypertension, hepatic or renal insufficiency. Third trimester of pregnancy.
Gastrointestinal problems like dyspepsia, abdominal pain, nausea, and diarrhea.
Yes, rarer side effects include dizziness, constipation, vomiting, ulcerative stomatitis, rash, dermatitis, headache, fatigue, allergic reactions, anemia, granulocytopenia, thrombocytopenia, neutropenia, edema, palpitations, leg cramps, flushing, purpura, paresthesia, tremors, gastrointestinal bleeding, gastrointestinal ulceration, pancreatitis, interstitial nephritis, depression, abnormal dreaming, somnolence, insomnia, vasculitis, hypoglycemia, and elevated blood urea, serum creatinine, and serum potassium levels.
It can cause dizziness, so avoid driving or operating machinery. Regular monitoring of renal function, liver function, and blood counts is required for patients on long-term treatment. Use with caution in patients with: Hepatic porphyria, coagulation disorders, history of peptic ulcers, ulcerative colitis, Crohn's disease, systemic lupus erythematosus (SLE), cerebrovascular bleeding, pregnancy, and lactation. Mild to moderate impairment of cardiac, hepatic, or renal function, and in elderly patients.
Aceclofenac: May increase plasma concentrations of lithium, digoxin, and methotrexate. May enhance the activity of anticoagulants. May inhibit the activity of diuretics. May increase cyclosporine nephrotoxicity. May precipitate convulsions when co-administered with quinolone antibiotics. Paracetamol: Increased risk of toxicity when co-administered with other hepatotoxic drugs or drugs that induce hepatic microsomal enzymes (e.g., rifampicin, isoniazid, chloramphenicol, anti-epileptic drugs, antiviral drugs). Absorption increased by metoclopramide, but excretion and plasma concentration altered by probenecid. Absorption reduced by cholestyramine.
No, co-administration with other NSAIDs or corticosteroids is to be avoided due to increased risk of side effects.
Nausea, vomiting, abdominal pain, dizziness, somnolence, headache, sweating, pancreatitis, hepatic failure, and acute renal failure.
Gastric lavage, activated charcoal, and other symptomatic measures as per medical advice.
Below 30°C, protected from light and moisture. Keep out of reach of children.
1x10 tablets.