Lofnac-100 suppositories rectal #10

What is Lofnac-100 and what does it contain?

Lofnac-100 is a rectal suppository containing diclofenac sodium, a non-steroidal anti-inflammatory drug (NSAID). It contains 100 mg of diclofenac sodium and various excipients.

How does Lofnac-100 work?

Lofnac-100 inhibits the enzyme cyclooxygenase, reducing prostaglandin production and alleviating pain, inflammation, and fever.

How is Lofnac-100 absorbed and eliminated from the body?

Lofnac-100 is absorbed rapidly rectally, reaching peak plasma concentrations within 1 hour. It is extensively bound to plasma proteins and eliminated through urine and feces.

What are the indications for using Lofnac-100?

Lofnac-100 is indicated for pain and inflammation relief in various conditions, including arthritis, gout, chronic polyarthritis, Bechterew's disease, inflammatory rheumatoid disorders, degenerative joint disorders, soft tissue rheumatism, and post-injury/surgery inflammation.

What are the recommended dosages of Lofnac-100 for adults and children?

**Adults:** 75-150 mg daily, divided into multiple doses, maximum 150 mg daily. **Children:** Lofnac 12.5/25 is preferred. 1-3 mg/kg per day for juvenile chronic arthritis, 1-2 mg/kg per day for acute post-operative pain (max 4 days).

How should Lofnac-100 suppositories be administered?

Lofnac-100 suppositories should be inserted rectally after bowel clearance, following instructions in the text.

What are the contraindications for using Lofnac-100?

Lofnac-100 is contraindicated in cases of hypersensitivity, active gastrointestinal ulcers, history of NSAID-related bleeding, active peptic ulcer/haemorrhage, last trimester pregnancy, severe hepatic/renal/cardiac failure, asthma/angioedema/urticaria triggered by NSAIDs, proctitis, and established congestive heart failure.

What are the precautions and warnings associated with Lofnac-100?

Caution is advised for elderly patients, patients with gastrointestinal disorders, history of ulceration/bleeding, impaired hepatic/renal function, and systemic lupus erythematosus.

What are the potential side effects of Lofnac-100?

Common side effects include headache, dizziness, increased transaminases, nausea, vomiting, diarrhea, and rash. Rare or very rare side effects include anemia, agranulocytosis, hypersensitivity, edema, depression, disturbances, hallucinations, and many others.

What are the potential interactions of Lofnac-100 with other drugs?

Lofnac-100 should be used cautiously with lithium, digoxin, diuretics, anti-hypertensives, antibacterial, phenytoin, colestipol, cholestyramine, cardiac glycosides, potent CYP2C9 inhibitors, glucocorticoids, methotrexate, acetyl-salicylic acid, other NSAIDs, SSRIs, cyclosporin, tacrolimus, drugs causing hyperkalemia, and quinolone. Avoid use for 8-12 days after mifepristone administration.

What are the effects of Lofnac-100 on pregnancy and lactation?

Lofnac-100 is contraindicated in the last trimester of pregnancy. It passes into breast milk and should not be administered during pregnancy or breastfeeding.

What should I do if I accidentally take too much Lofnac-100?

Overdosage can cause various symptoms like headache, nausea, vomiting, gastrointestinal bleeding, dizziness, disorientation, excitation, coma, drowsiness, tinnitus, fainting, or convulsions. In case of significant poisoning, acute renal failure and liver damage are possible. Seek immediate medical attention.

Where can I find more information about Lofnac-100?

Consult the patient information leaflet or speak to your healthcare professional.