Advant 16 mg tabl. #28
Manufacturer: Getz Pharma, Pakistan
Composition: candesartan 16.0 mg
What is Advant, and how does it work?
Advant is the brand name for Candesartan Cilexetil, a medication used to treat hypertension (high blood pressure). It works by blocking the effects of angiotensin II, a hormone that causes blood vessels to constrict, leading to increased blood pressure. Candesartan specifically blocks the AT1 receptor, which is responsible for angiotensin II's effects on blood pressure regulation.
What is the chemical composition of Advant?
Advant (Candesartan Cilexetil) is a nonpeptide compound chemically described as (±)-1-Hydroxyethyl 2-ethoxy-1-[p-(0-1H-tetrazol-5-ylphenyl)benzyl]-7-benzimidazolecarboxylate, cyclohexyl carbonate (ester). Its molecular formula is C33H34N6O8.
How is Advant administered, and what is the recommended starting dose?
Advant tablets can be taken with or without food. The usual recommended starting dose for monotherapy in patients who are not volume-depleted is 16mg once daily.
How is Advant metabolized and excreted?
Advant is rapidly and completely bioactivated by ester hydrolysis during absorption from the gastrointestinal tract to candesartan. About 26% of the dose is excreted unchanged in urine. The elimination half-life of candesartan is approximately 9 hours.
Are there any special considerations for patients with renal or hepatic impairment?
Patients with severe renal impairment (creatinine clearance <30mL/min/1.73m) may experience elevated serum concentrations of candesartan. No initial dosage adjustment is necessary for patients with mild renal insufficiency.
For patients with moderate hepatic impairment, consideration should be given to initiating Advant at a lower dose. No initial dose adjustment is necessary for patients with mild hepatic impairment.
Are there any drug interactions to be aware of?
Candesartan is not significantly metabolized by the cytochrome P450 system and does not affect P450 enzymes at therapeutic concentrations. However, careful monitoring of serum lithium levels is recommended during concomitant use with Advant due to potential increases in lithium concentration and toxicity.
What are the potential side effects of Advant?
Advant is generally well tolerated, with common side effects being mild and transient, such as headache and dizziness. Potentially important adverse events reported with Advant include asthenia, fever, paresthesia, vertigo, dyspepsia, gastroenteritis, tachycardia, palpitations, increased creatinine phosphokinase, hyperglycemia, hypertriglyceridemia, hyperuricemia, myalgia, epistaxis, anxiety, depression, somnolence, dyspnea, rash, increased sweating, and hematuria. Rare side effects include abnormal hepatic function, hepatitis, neutropenia, leukopenia, agranulocytosis, hyperkalemia, hyponatremia, renal impairment, renal failure, pruritus, and urticaria.
What should be done in case of an overdose?
The most likely manifestation of overdosage with Advant would be hypotension, dizziness, and tachycardia. Bradycardia could occur from parasympathetic stimulation. If symptomatic hypotension occurs, supportive treatment should be instituted. Candesartan cannot be removed by hemodialysis.
Are there any contraindications for using Advant?
Advant is contraindicated in patients who are hypersensitive to this drug or any component of the product. It is also contraindicated in pregnancy during the second and third trimesters.
What is the storage information for Advant?
Advant should be stored below 30°C, protected from sunlight and moisture.
What is the price of Advant 16 mg tabl. #28?
The price of Advant 16 mg tabl. #28 is ₦ 5775.00, exclusively for online orders through the Intaila mobile application