Celebrex 200 mg capsules #10
Manufacturer: Pfizer, Germany
Composition: celecoxib 200.0 mg
What are the therapeutic indications for Celebrex?
Symptomatic treatment of osteoarthritis (OA) and rheumatoid arthritis (RA), Relief of signs and symptoms of ankylosing spondylitis (AS), Management of acute pain, Treatment of primary dysmenorrhea
What is the recommended dosage of Celebrex for different indications?
Osteoarthritis (OA): 200 mg once daily or 100 mg twice daily. Rheumatoid Arthritis (RA): 100 mg or 200 mg twice daily. Ankylosing Spondylitis (AS): 200 mg once daily or 100 mg twice daily. Some patients may benefit from 400 mg total daily dose. Management of Acute Pain: 400 mg initially, followed by an additional 200 mg dose if needed on the first day. On subsequent days, 200 mg twice daily as needed. Treatment of Primary Dysmenorrhea: 400 mg initially, followed by an additional 200 mg dose if needed on the first day. On subsequent days, 200 mg twice daily as needed.
What are the most common side effects associated with Celebrex?
Gastrointestinal disorders: Diarrhea, vomiting, abdominal pain, dyspepsia, flatulence. Respiratory, thoracic and mediastinal disorders: Cough, dyspnea. Hepatobiliary disorders: Hepatic enzyme increased (includes alanine aminotransferase increased and aspartate aminotransferase increased). Skin and subcutaneous tissue disorders: Pruritus, rash, urticaria. Musculoskeletal and connective tissue disorders: Muscle spasms.
What are the serious cardiovascular risks associated with Celebrex?
Increased risk of serious cardiovascular thrombotic events, including myocardial infarction (heart attack) and stroke, which can be fatal.
How does Celebrex affect the gastrointestinal system?
NSAIDs, including Celebrex, can cause an increased risk of serious gastrointestinal adverse events such as bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
What special precautions should be taken when using Celebrex?
Use with caution in patients with cardiovascular disease or risk factors. Use with caution in patients with a history of gastrointestinal problems, including ulcers or bleeding. Use with caution in patients with moderate hepatic impairment (Child-Pugh Class B) and initiate at half the recommended dose. Avoid in patients with severe hepatic impairment (Child-Pugh Class C). Use with caution in patients with advanced renal disease. Monitor renal function closely. Monitor for fluid retention and edema, especially in patients with pre-existing congestive heart failure or hypertension. Initiate therapy at the lowest recommended dose for elderly patients weighing less than 50 kg. Avoid Celebrex during the third trimester of pregnancy. Celebrex is excreted in breast milk. A decision should be made whether to discontinue nursing or the drug, considering the benefits to the mother.
What are the contraindications for Celebrex?
Patients with known hypersensitivity to celecoxib or any ingredient in the product. Patients with known sulfonamide hypersensitivity. Patients who have experienced asthma, urticaria, or allergic-type reactions after taking acetylsalicylic acid (ASA) or other NSAIDs. Treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
How does Celebrex interact with other medications?
Oral anticoagulants: Increases the risk of bleeding. Monitor anticoagulation/INR closely. CYP2C9 inhibitors (fluconazole): Increases celecoxib plasma concentration. Consider starting at half the recommended dose. CYP2D6 substrates (dextromethorphan, metoprolol): Increases plasma concentrations of these drugs. Dose reduction may be needed. Diuretics: May reduce the natriuretic effect of diuretics. ACE inhibitors and angiotensin II antagonists: May increase the risk of renal toxicity. Lithium: Increases lithium plasma levels. Monitor lithium treatment closely.
What should I do in case of overdose?
Provide appropriate supportive medical care. Dialysis is unlikely to be effective.
What are the long-term cardiovascular safety concerns with Celebrex?
Long-term studies involving patients with sporadic adenomatous polyps (APC and PreSAP trials) and Alzheimer's disease (ADAPT study) have shown mixed results regarding cardiovascular safety. The overall risk of cardiovascular events with Celebrex compared to other NSAIDs remains a subject of ongoing research and debate.
How does Celebrex affect platelet function?
Celebrex does not inhibit platelet aggregation. Therefore, it is not a substitute for acetylsalicylic acid (aspirin) for the prophylaxis of cardiovascular thromboembolic diseases.
What is the mechanism of action of Celebrex?
Celebrex inhibits prostaglandin synthesis primarily by inhibiting COX-2. It does not inhibit COX-1 at therapeutic concentrations. COX-2 is induced in response to inflammatory stimuli, leading to the production of inflammatory prostanoids, which cause inflammation, edema, and pain. Celecoxib blocks the production of these prostanoids by inhibiting COX-2, resulting in its anti-inflammatory, analgesic, and antipyretic effects.
What is the price of Celebrex 200 mg capsules #10?
The price of Celebrex 200 mg capsules #10 is ₦ 9375.00, exclusively for online orders through the Intaila mobile application