Cethar sol. for inj. ampoules 1.0 ml #6
Manufacturer: Pharmax India Private, India
Composition: artemether 80.0 mg/ml
What is the active ingredient in Cethar Sol.?
Artemether
What is the chemical structure of Artemether?
Sesquiterpene lactone with an endoperoxide bridge; methyl ether of Dihydroartemisinin
What is the mechanism of action of Artemether?
Kills asexual erythrocytic forms of the Plasmodium parasite by inhibiting protein synthesis during trophozoite growth.
What is the recommended route of administration for Cethar Sol.?
Intramuscular (IM) use only.
What are the indications for using Cethar Sol.?
Treatment of severe malaria, including cerebral malaria; second-line drug for chloroquine-resistant malaria.
What is the recommended dosage for adults and children using Cethar Sol.?
Adults: Not more than 480mg over 5 days. Children: Not more than 9.6mg/kg body weight over 5 days.
How is Cethar Sol. typically administered?
Aseptically in the upper external quadrant of the buttock. Do not mix with other drugs in the same syringe.
What are some potential drug interactions with Cethar Sol.?
Avoid medications that prolong the QT interval, including: Erythromycin, Terfenadine, Astimizole, Probucol, Class 1a anti-arrhythmic agents, Bepridil, Sotalol, Tricyclic antidepressants, some neuroleptics and phenothiazines.
What are the potential adverse drug reactions associated with Cethar Sol.?
Decrease in reticulocyte count, slight rise in SGPT. Rare cases of cardiotoxicity with high doses.
What are the precautions and warnings associated with Cethar Sol.?
Do not exceed prescribed dose. Urgent symptomatic treatment needed for overdose. Electrocardiographic QT prolongation reported. Safety during breastfeeding unknown, caution advised.
Who should not take Cethar Sol.?
Contraindicated in pregnancy except in essential cases (e.g., cerebral malaria).
How should Cethar Sol. be stored?
Cool and dry place, out of reach of children. Do not use if particles are visible.