Chloramphenicol Sodium Succinate 1 gm powder for injection and infusion bottle #1
Manufacturer: Laborate Pharmaceuticals, India
Composition: chloramphenicol 1000.0 mg
What is the active ingredient in this medication?
Chloramphenicol Sodium Succinate
What is the strength of this medication?
1 gm
What types of bacteria is this medication effective against?
Gram-positive and Gram-negative bacteria, anaerobic organisms, Spirillae and Rickettsia.
How does this medication work?
Interfering with bacterial protein synthesis.
Where does this medication distribute in the body?
Widely distributed throughout body tissues and fluids, including cerebrospinal fluid.
What is the half-life of Chloramphenicol and Chloramphenicol Succinate?
Chloramphenicol: 4.03 hours Chloramphenicol Succinate: 2.65 hours
What is the peak concentration reached after intravenous administration?
18.0 minutes after cessation of the infusion.
What are the main indications for using this medication?
Typhoid fever, Meningitis, Staphylococcal brain abscesses, Severe penicillin or cephalosporin allergy, Vancomycin-resistant enterococcus infections.
When is this medication contraindicated?
Previous history of sensitivity or toxic reaction to Chloramphenicol.
What are the potential drug interactions with this medication?
Coumarin anticoagulants, Tolbutamide, Phenytoin, Phenobarbital, Rifampicin.
What are the potential adverse reactions associated with this medication?
Dryness of the mouth, Nausea, Vomiting, Diarrhea, Urticaria, Optic neuritis, Peripheral neuritis, Headache, Depression, Leukemia, Bone marrow depression, Aplastic anemia, Superinfection by fungi, Grey syndrome.
What are the special precautions for using this medication?
Dosage should be reduced for impaired hepatic or renal function. Serum levels should be monitored in newborns, premature infants, elderly patients, patients with renal or hepatic disease, and those receiving other interacting drugs. Keep out of reach of children.
What are the symptoms of overdose and what is the antidote?
General supportive therapy.
How is this medication administered?
Dry powder reconstituted with sterile water for injection.
What are the recommended dosages for adults, elderly, children, neonates, and premature infants?
Adults: 1 g every 6-8 hours. Elderly: Usual adult dosage. Children: 50 mg/kg/day in divided doses every 6 hours. Neonates & Premature Infants: 25 mg/kg in divided doses. Or as directed by the physician.
What is the presentation of this medication?
10 vials in a carton with a patient information leaflet.
How should this medication be stored?
Dark and dry place at a temperature not exceeding 25°C.
Who is the manufacturer of this medication?
EMBASSY PRATICAL & CHEMICALS L PHARMACEUTICAL (INDIA)
What is the NAFDAC registration number for this medication?
04-5352.