Gabapentin 300 mg tabl. #100
Manufacturer: Bafna Pharmaceuticals, India
Composition: gabapentin 300.0 mg
What is the composition of Biopentin Tablets?
Each film-coated tablet contains Gabapentin 300 mg and Methylcobalamin 500 mcg, along with excipients, Sunset Yellow & Titanium dioxide BP.
What conditions does Biopentin treat?
Diabetic and non-diabetic neuropathic pain and postherpetic neuralgia.
How does Biopentin work?
Gabapentin binds to alpha 2 delta subunits of voltage-gated calcium channels, inhibiting glutamate release in the CNS. It also stabilizes the nerve membrane by inhibiting calcium ion channels, minimizing abnormal nerve impulses. Methylcobalamin is the neurologically active form of vitamin B12, which increases myelin sheath formation, regenerates neurons, and prevents progressive nerve damage.
How is Biopentin administered?
Orally with or without food.
What are the recommended dosages of Gabapentin and Methylcobalamin in Biopentin?
Starting dose: one tablet per day, increasing to one tablet twice daily on day 2, and one tablet three times daily on day 3. Average effective dose of methylcobalamin: 1500 mcg/day (at least 3 tablets per day).
What are some common side effects of Biopentin?
Somnolence, dizziness, ataxia, fatigue, nystagmus, tremor, diplopia, amblyopia, pharyngitis, weakness, arthralgia, paraesthesia, purpura, leucopenia, anxiety, and UTI.
Are there any contraindications for Biopentin?
Hypersensitivity to cobalamin products or Gabapentin or any component of the preparation. Tobacco amblyopia. Should not be administered before pernicious anemia or folate deficiency has been ruled out. Contraindicated in breast-feeding, pregnancy, carcinogenicity, when driving, and with alcohol.
How does methylcobalamin contribute to nerve function?
It contributes to nerve myelination, stimulates protein synthesis for neural regeneration and repair, and regenerates neurons and the myelin sheath that protects nerve axons and peripheral nerves.
What is Gabapentin's molecular formula and weight?
C9H17NO2; 171.24
What was the purpose of the study mentioned in the text?
To investigate the effectiveness of methylcobalamin in treating diabetic neuropathy.
What were the results of the study?
Oral administration of methylcobalamin (500 mcg three times daily for four months) resulted in subjective improvement in burning sensations, numbness, loss of sensation, and muscle cramps. There was also an improvement in reflexes, vibration sense, lower motor neuron weakness, and sensitivity to pain in the treatment group compared to placebo.
What is the recommended duration of treatment with Biopentin?
Not mentioned in the text.
What are the potential long-term effects of Biopentin?
Not detailed in the text.
What are the potential drug interactions with Biopentin?
Cimetidine, ranitidine, phenobarbitone, primidone, phenytoin, ethylphenacemide, oral contraceptives, and tetracycline.
How does Biopentin affect the body's metabolism?
Gabapentin is not appreciably metabolized and does not interfere with the metabolism of commonly co-administered antiepileptic drugs.
Is Biopentin safe for use in children?
Safety and effectiveness in children have not been established.
What should I do if I suspect an overdose of Biopentin?
Seek immediate medical attention.