GJL Alpha Beta Arteether sol. for inj. ampoules 2.0 ml #3
Manufacturer: Faes Farma, Spain
Composition: arteether 75.0 mg/ml
What is the active ingredient in GJL Alpha Beta Arteether injection?
Answer: a-ß Arteether, 150 mg in each 2 ml ampoule.
What is the vehicle used for the injection?
Answer: Arachis Oil B.P. (Peanut oil).
How is the injection administered?
Answer: Deep intramuscularly in the upper lateral quadrant of the buttock under aseptic conditions.
Can other medications be mixed with GJL Alpha Beta Arteether injection in the same syringe?
Answer: No.
What is the pharmacological class of GJL Alpha Beta Arteether injection?
Answer: Antimalarial drug.
What is the mechanism of action of a-ß Arteether?
Answer: Fast-acting blood schizonticidal agent targeting the erythrocytic stage of Plasmodium falciparum malaria.
How does a-ß Arteether affect the parasite's cell?
Answer: Releases a highly reactive free radical iron species that causes lysis of the parasitic cell. Additionally, it inhibits protein synthesis and alters the ribosomal organization and endoplasmic reticulum.
Are there any known neurotoxic effects of a-ß Arteether in humans?
Answer: No evidence of neurotoxicity in humans.
What are the most common side effects associated with GJL Alpha Beta Arteether injection?
Answer: Nausea, dizziness, depressed gastrointestinal activity.
Are there any significant hematological abnormalities associated with GJL Alpha Beta Arteether injection?
Answer: No significant abnormalities apart from some increase in eosinophil numbers.
How is a-ß Arteether metabolized and eliminated from the body?
Answer: Transformed into dihydroartemisinin and eliminated by hepatic metabolism.
What is the half-life of a-ß Arteether?
Answer: 20 hours.
What are the potential drug interactions with GJL Alpha Beta Arteether injection?
Answer: Caution should be exercised against combinations with drugs that prolong the QT interval (e.g., quinine, halofantrine).
What conditions is GJL Alpha Beta Arteether injection used to treat?
Answer: Severe and uncomplicated falciparum malaria, including strains resistant to other antimalarials.
How is GJL Alpha Beta Arteether injection dosed for children?
Answer: 3 mg/kg per day administered intramuscularly over a 3-day period.
What is the recommended treatment for overdose of GJL Alpha Beta Arteether injection?
Answer: Symptomatic and supportive.
When is GJL Alpha Beta Arteether injection contraindicated?
Answer: Hypersensitivity to artemisinin derivatives.
What are the recommended storage conditions for GJL Alpha Beta Arteether injection?
Answer: Store below 30°C in a cool place, protected from light. Keep out of reach of children.
What is the shelf life of GJL Alpha Beta Arteether injection?
Answer: 36 months.