Labohydro sol. for inj. #1
Manufacturer: Laborate Pharmaceuticals, India
Composition: hydrocortisone 100.0 mg/ml
What is the active ingredient in Labohydro?
Hydrocortisone sodium succinate BP (equivalent to 100mg Hydrocortisone)
What is the dosage form and strength?
Powder for injection, 100mg strength
What is the ATC code?
Not provided.
What is the primary mechanism of action?
It suppresses inflammatory and immune responses by inhibiting mediators and phagocytes, leading to reduced inflammation.
How does Labohydro's absorption differ between intravenous and intramuscular administration?
Intravenous administration is faster (peak within 0.25-0.37 hours) compared to intramuscular (peak in 30-60 minutes).
Does gender affect Labohydro's metabolism?
Yes, females have higher plasma concentrations after a 25mg IV dose compared to males.
What are the primary indications for Labohydro?
Relief of inflammatory and pruritic symptoms in corticosteroid-responsive dermatoses. Treatment of endocrine disorders like adrenal insufficiency. Management of immune and allergic disorders like arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
Who should not receive Labohydro?
Patients with hypersensitivity to corticosteroids or any excipient. Patients with systemic fungal infections. Premature infants.
How can Labohydro interact with other medications?
Thiazides: May enhance hyperglycemia and hypokalemia. NSAIDs: Increased risk of peptic ulcers and GI bleeding. Anticoagulants: Altered response to anticoagulants. Antidiabetics & Bentonpeeds: Increased dosage may be required. Salicylates: Labohydro decreases their serum concentrations. Ethanol: May enhance gastric mucosal irritation. Carbamazepine, phenytoin, primidone, barbiturates, rifampicin: Reduced efficacy of Labohydro. Ciclosporin: Mutual inhibition of metabolism, increasing plasma concentrations of both drugs. Estrogens or oral contraceptives: Enhanced effect of Labohydro in women taking these medications.
What are the potential risks associated with Labohydro use?
Dermal/subdermal changes at injection site, leading to skin depressions. Elevated blood pressure, salt and water retention, increased potassium excretion. Cushing's syndrome, hyperglycemia. Increased susceptibility to infections. Restricted use in patients with active tuberculosis, chickenpox, and measles.
Is Labohydro recommended during pregnancy or lactation?
Not recommended in either case.
What precautions should be taken when administering Labohydro?
Use cautiously in patients with congestive heart failure, hypertension, renal insufficiency, active/latent peptic ulcers, nonspecific ulcerative colitis. Monitor for drug-induced secondary adrenocortical insufficiency, especially when reducing dosage gradually. Monitor intraocular pressure if steroid therapy continues for more than 6 weeks.
What are the common and serious side effects of Labohydro?
Common: Stomach upset, headache, dizziness, menstrual period changes, trouble sleeping. Serious: Incoordination, black stools, severe stomach/abdominal pain, increased appetite, weight gain, injection site pain/redness/swelling, thirst/urination, fast/slow/irregular heartbeat, shortness of breath, ankle/foot swelling, tendon pain, persistent weight gain, unusual hair growth, thinning skin, slow wound healing, signs of infection, muscle weakness/pain, mental/mood changes, seizures, unusual skin growths.
What is the typical dosage range for Labohydro?
100mg to 500mg intravenously over 1-10 minutes, repeated every 2-6 hours based on patient response and condition.
Are dosage adjustments necessary for elderly or pediatric patients?
Elderly: No specific adjustments needed for acute short-term use. Children: Dosage may be reduced but primarily based on condition severity and response rather than age or weight, with a minimum daily dose of 25mg.
How is Labohydro prepared for administration?
The dry powder should be reconstituted immediately before use with sterile water for injection.
What is the packaging and storage condition of Labohydro?
Packaged in 10 vials in a carton with patient information leaflet. Store below 25°C.
Who manufactures Labohydro?
Laborate Pharmaceutical (India) Pharmaceutical & Chemicals Ltd.