Levolab solution for infusion bottle 100.0 ml #1
Manufacturer: Laborate Pharmaceuticals, India
Composition: levofloxacin 5.0 mg/ml
What is Levolab Infusion 500mg/100ml used for?
- Community-acquired pneumonia
- Complicated skin and soft tissue infections
- Pyelonephritis and complicated urinary tract infections
- Chronic bacterial prostatitis
- Inhalation anthrax (postexposure prophylaxis and curative treatment)
How does Levolab Infusion work?
- It inhibits bacterial DNA synthesis by targeting DNA gyrase and topoisomerase IV.
What are the contraindications for using Levolab Infusion?
- Hypersensitivity to levofloxacin, other quinolones, or excipients
- Epilepsy
- History of tendon disorders associated with fluoroquinolone use
- Children and adolescents
What are some important drug interactions to consider with Levolab Infusion?
- Increased concentration: Ciclosporin, tacrolimus
- Reduced absorption: Didanosine, ferrous sulfate, zinc, calcium, magnesium, iron supplements
- Increased plasma levels: Theophylline
- Increased tendon rupture risk: Corticosteroids
- Reduced absorption: Sucralfate, antacids containing magnesium and aluminum
- Increased half-life and decreased clearance: Procainamide
- Altered glucose levels: Insulin, glyburide
- Potentially Fatal: QT prolonging drugs (Class IA and Class III antiarrhythmics, fluoxetine, imipramine)
- Increased risk of CNS stimulation and seizures: NSAIDs
- Increased prothrombin time: Warfarin
What are the potential side effects of Levolab Infusion?
- Common: Nausea, diarrhea, constipation, headache, insomnia, injection site reactions
- Ophthalmic: Transient decrease in vision, ocular burning, ocular pain, foreign body sensation, headache, fever, pharyngitis, photophobia
- Potentially Fatal: Anaphylaxis
What are the symptoms of overdose and what is the antidote?
- Symptoms: Confusion, dizziness, impairment of consciousness, seizures, QT prolongation
- Antidote: No specific antidote, treatment is symptomatic. ECG monitoring is essential.
How should Levolab Infusion be stored?
- Store in a cool, dry, and dark place below 30°C. Protect from light.
What are some important precautions to take while using Levolab Infusion?
- Avoid unnecessary exposure to sunlight or UV light
- Monitor blood glucose levels in patients with diabetes
- Monitor renal, hepatic, and hematologic function
- Use with caution during pregnancy and lactation
- May impair the ability to drive or operate machinery
What is the composition of Levolab Infusion?
- Levofloxacin Hemihydrate (equivalent to Levofloxacin): 500mg
- Sodium Chloride BP: 0.9gm
- Water for Injection BP: q.s.
What is the presentation of Levolab Infusion?
- Available as a 100ml intravenous infusion solution in a bottle.