Libre tabl. #10
Manufacturer: Ratnamani Healthcare PVT LTD, India
Composition: tizanidine 2.0 mg
What is the mechanism of action of tizanidine?
Tizanidine is a centrally acting muscle relaxant that works by stimulating presynaptic alpha2-receptors in the spinal cord, inhibiting the release of excitatory amino acids and reducing muscle tone.
How is tizanidine metabolized and eliminated from the body?
Tizanidine is metabolized in the liver by cytochrome P450 1A2 and primarily excreted through the kidneys with a half-life of 2-4 hours.
What are the potential drug interactions of tizanidine?
Tizanidine interacts with CYP1A2 inhibitors, antihypertensives, alcohol, and sedatives.
What are the potential side effects of tizanidine?
Common side effects include somnolence, dizziness, headache, nausea, and gastrointestinal disorders. Less common side effects include hypotension, bradycardia, tachycardia, ataxia, dysarthria, accommodation disorders, and muscle weakness. Serious side effects include hallucinations, insomnia, sleep disorders, hepatitis, hepatic failure, and rebound hypertension.
What are the contraindications for tizanidine?
Tizanidine is contraindicated in patients with significant hepatic impairment and those taking strong CYP1A2 inhibitors.
What are the special warnings and precautions for tizanidine use?
Tizanidine requires careful monitoring due to potential side effects and interactions, particularly with CYP1A2 inhibitors. Rebound hypertension and tachycardia can occur after sudden withdrawal, so it should be discontinued gradually.
What are the recommended dosages and administration guidelines for tizanidine?
Dosage is individualized, typically starting at 2 mg and titrated up to a maximum of 36 mg daily. It is not recommended for children or elderly patients unless the benefit outweighs the risk.
What are the possible symptoms of tizanidine overdose?
Overdose symptoms include nausea, vomiting, hypotension, bradycardia, QT prolongation, dizziness, miosis, respiratory distress, coma, restlessness, and somnolence.
What is the treatment for tizanidine overdose?
Overdose treatment focuses on supportive measures such as maintaining airway, breathing, and circulation, decontamination with gastric lavage or activated charcoal, hydration, and symptomatic treatment.
What is the price of Libre tabl. #10?
The price of Libre tabl. #10 is ₦ 1787.50, exclusively for online orders through the Intaila mobile application