Oxyurea 500 mg capsules #30
Manufacturer: Polybond, India
Composition: hydroxyurea 500.0 mg
What is the active ingredient in Oxyurea capsules?
Answer: Hydroxyurea
What are the different strengths available for Oxyurea capsules?
Answer: 100mg, 250mg, and 500mg.
What is the package size for each strength of Oxyurea capsules?
Answer: 30 capsules per pack for all strengths.
Who is the manufacturer of Oxyurea capsules?
Answer: BOND CHEMICAL IND. LTD., located in Awe, Oyo State, Nigeria.
What are the main indications for Oxyurea capsules?
Answer: Prevention of recurrent painful vaso-occlusive crises in patients with Sickle Cell Syndrome, treatment of melanoma, resistant chronic myelocytic leukemia, recurrent metastasized or inoperable carcinoma of the ovary, and local control of squamous cell carcinomas of the head and neck when used concurrently with radiation therapy.
What age group can Oxyurea capsules be used in for Sickle Cell Syndrome?
Answer: Adults, adolescents, and children older than 2 years.
How does Oxyurea work to reduce the frequency of vaso-occlusive crises in Sickle Cell Syndrome patients?
Answer: It increases fetal hemoglobin (HbF) levels, which interferes with the polymerization of HbS and thus prevents the sickling of red blood cells.
What other pharmacological effects of Oxyurea contribute to its benefits in Sickle Cell Syndrome?
Answer: It reduces neutrophil count, increases water content of erythrocytes, improves deformability of sickled cells, and alters adhesion of red blood cells to the endothelium.
How does Oxyurea affect DNA synthesis?
Answer: It inhibits DNA synthesis by acting as a ribonucleotide reductase inhibitor, but does not interfere with RNA or protein synthesis.
How is the dosage of Oxyurea determined?
Answer: Dosage is based on the patient's actual or ideal weight, whichever is less.
What are the different dosage schedules for Oxyurea in solid tumor treatment?
Answer: Intermittent therapy: 80mg/kg every third day. Continuous therapy: 20-30mg/kg daily. Concomitant therapy: 80mg/kg every third day, starting at least 7 days before irradiation and continuing during and after radiation therapy.
What is the recommended dosage for Oxyurea in resistant chronic myelocytic leukemia?
Answer: Continuous therapy (20-30mg/kg daily) is recommended until intermittent therapy has been evaluated.
Who should not use Oxyurea?
Answer: Patients with marked bone marrow depression (leucopenia <2500 WBC or thrombocytopenia <100,000), and patients with severe anemia.
What precautions should be taken when using Oxyurea?
Answer: Do not initiate treatment if bone marrow function is significantly depressed. Use cautiously in patients who have previously received radiotherapy or cytotoxic chemotherapy. Correct severe anemia with blood replacement before starting Oxyurea therapy. Use with caution in patients with marked renal dysfunction. Elderly patients may be more sensitive and require a lower dose.
What are the possible side effects of Oxyurea?
Answer: Psycho-neurological: Headache, dizziness, hallucinations, and convulsions. Gastrointestinal: Stomatitis, inappetence, nausea, vomiting, diarrhea, and constipation. Hematologic: Bone marrow depression (leucopenia, anemia, and thrombocytopenia), megaloblastic erythropoiesis. Urogenital: Dysuria, alopecia, impaired renal tubular function, elevated serum uric acid, BUN, and creatinine levels. Central Nervous System: Lethargy, flush, chill, malaise. Dermatologic: Maculopapular rash, facial erythema. Hepatic: Abnormal BSP retention, elevated hepatic enzymes.
What monitoring is required during Oxyurea therapy?
Answer: Close supervision is needed, including monitoring blood counts (including bone marrow examination if indicated), kidney function, and liver function before and repeatedly during treatment.
What should be done if the white blood cell count or platelet count falls below certain levels?
Answer: Therapy should be interrupted until the values rise significantly towards normal levels.
How is anemia managed during Oxyurea therapy?
Answer: Anemia should be managed with whole blood replacement without interrupting Oxyurea therapy.
How should patients handle Oxyurea capsules?
Answer: They should handle the medication with care and avoid contact of the powder with skin or mucous membranes.
What measures can be used to manage mucositis?
Answer: Topical anesthetics and oral analgesics can usually control mucositis. If severe, Oxyurea therapy may be temporarily interrupted, and irradiation may be postponed in extreme cases.
What are the potential risks of Oxyurea for pregnant women?
Answer: Oxyurea may be a potential mutagenic and teratogenic agent. It should be used in women who are or may become pregnant only if the potential benefits outweigh the possible risks.
How should Oxyurea capsules be stored?
Answer: Store in well-closed containers at a temperature not exceeding 30°C. Keep all medications out of reach of children.
What is the price of Oxyurea 500 mg capsules #30?
The price of Oxyurea 500 mg capsules #30 is ₦ 4812.50, exclusively for online orders through the Intaila mobile application