P-Alaxin 40/320 tabl. #12
Manufacturer: Bliss Pharma Limited , India
Composition: dihydroartemisinin 40.0 mg + piperaquine 320.0 mg
What is the mechanism of action of Dihydroartemisinin?
Dihydroartemisinin disrupts the malaria parasite's membrane structures, leading to its self-destruction. It also inhibits protein and nucleic acid synthesis.
What are the contraindications for P-Alaxin?
First-trimester pregnancy, hypersensitivity to its components, history of cardiac arrhythmias or bradycardia, and concurrent use of QTc-prolonging medications.
What is the recommended dosage of P-Alaxin for a child weighing 20 kg?
1.5 tablets per day for three days (4.5 tablets total).
What are the potential adverse reactions associated with P-Alaxin?
Nausea, vomiting, reduced reticulocyte counts, dizziness, vertigo, headache, abdominal discomfort, leucopenia, dyspnea, and palpitations.
How are Dihydroartemisinin and Piperaquine Phosphate absorbed and eliminated from the body?
Dihydroartemisinin is rapidly absorbed, reaching peak concentration in 1 hour, with a half-life of 4 hours. It's excreted in urine and feces. Piperaquine Phosphate is 80-90% absorbed within 24 hours, with a half-life of 20-22 days. It's eliminated through bile.
What are the indications for using P-Alaxin?
Treatment of malaria caused by P. falciparum, P. vivax, and P. malariae.
What precautions should be taken regarding pregnancy and lactation when using P-Alaxin?
Avoid during the first trimester if possible. Do not breastfeed during treatment.
What should be done in case of an overdose of P-Alaxin?
Symptomatic and supportive therapy, including ECG monitoring.
How should P-Alaxin be stored?
In light-resistant containers below 30°C, out of reach of children.
What is the composition of each P-Alaxin tablet?
40 mg Dihydroartemisinin, 320 mg Piperaquine Phosphate, and excipients.
What is the mechanism of action of Piperaquine Phosphate?
Interferes with the malaria parasite's food vacuole membrane, leading to its autophagocytosis.
What is the presentation of P-Alaxin?
Blister packs of 6, 9, 12, and 15 tablets within a carton, with a patient information leaflet.