Pardopa-275 capsules #30
Manufacturer: Micro Labs, India
Composition: levodopa 250.0 mg + carbidopa 25.0 mg
What is the brand name of this medication?
Pardopa-275
What are the active ingredients in Pardopa-275?
Levodopa BP 250 mg Carbidopa BP 25 mg
What is the dosage form of Pardopa-275?
Uncoated Tablets
What is the primary use of Pardopa-275?
Treatment of Parkinson's disease and Parkinsonian syndrome.
What is the mechanism of action of Pardopa-275?
Levodopa is a precursor of dopamine, used as a replacement therapy in Parkinson's disease. Carbidopa inhibits the peripheral decarboxylation of Levodopa into dopamine, ensuring a larger proportion of the administered dose reaches the brain, where dopamine acts.
What is the recommended route of administration for Pardopa-275?
Oral
How is the optimal daily dosage of Pardopa-275 determined?
Through careful titration in each patient.
How is the dosage of Pardopa-275 adjusted for patients not currently taking Levodopa?
Initiate with one 25 mg/100 mg tablet three times daily. Increase dosage by one 12.5 mg/50 mg or 25 mg/100 mg tablet daily or every other day, as needed, until a dosage of eight 25 mg/100 mg tablets in a day is reached.
What are some common side effects of Pardopa-275?
Nausea, vomiting, dyskinesia, orthostatic hypotension, hallucinations, confusion, anxiety, insomnia, drowsiness.
What are some less common side effects of Pardopa-275?
Muscle cramps, tremor, sweating, urinary retention, constipation, dry mouth, weight loss, depression, behavioral changes.
What is a rare but serious side effect of Pardopa-275?
Malignant neuroleptic syndrome-like symptoms (muscle rigidity, high body temperature, mental changes, elevated serum creatine phosphokinase).
What should patients be aware of regarding the potential for drowsiness and sleep episodes while taking Pardopa-275?
Patients experiencing drowsiness and/or sudden sleep episodes should not drive or operate machinery. Dosage reduction or discontinuation of treatment may be considered.
What should patients be aware of regarding the potential for impulse control disorders while taking Pardopa-275?
Patients should be monitored regularly for the development of impulse control disorders, including pathological gambling, increased libido, hypersexuality, compulsive spending and buying, binge eating, and compulsive eating. Treatment review is recommended if these symptoms develop.
What are some important precautions to take when administering Pardopa-275?
Monitor for mental changes, depression with suicidal tendencies, and other asocial behaviors. Use caution in patients with current psychoses. Patients with a history of severe involuntary movements or psychotic episodes while on Levodopa alone should be carefully observed when switching to Pardopa-275. Observe patients carefully, especially those also receiving neuroleptics, if a sudden dosage reduction or withdrawal of Pardopa-275 is necessary. Patients and healthcare providers should monitor for melanomas regularly while using Pardopa-275 for any indication. Patients with chronic open-angle glaucoma can be treated with caution, provided the intraocular pressure is well-controlled, and they are monitored closely for changes in intraocular pressure during treatment. Periodic evaluations of hepatic, hematopoietic, cardiovascular, and renal function are recommended during prolonged therapy.
What are some medications that may interact with Pardopa-275?
MAO inhibitors (non-selective), anticholinergics, antipsychotics (phenothiazines, butyrophenones, risperidone), antihypertensives, antidepressants (tricyclics), iron preparations, phenytoin, papaverine, agents known to deplete monoamine stores (tetrabenazine), selective MAO-B inhibitors (selegiline).
What should be considered when administering psychoactive medications such as phenothiazines or butyrophenones concomitantly with Pardopa-275?
Administration should be done with caution, and the patient should be closely observed for loss of antiparkinsonian effect.
What are the potential symptoms of Pardopa-275 overdose?
Similar to Levodopa overdose, but pyridoxine is not effective in reversing the effects.
What is the general treatment approach for Pardopa-275 overdose?
Monitor ECG and observe for arrhythmias. Administer appropriate anti-arrhythmic treatment if necessary. Consider the possibility of other drug ingestion in addition to Pardopa-275. The value of dialysis is not known.
What are some laboratory tests that may be affected by Pardopa-275?
Blood urea nitrogen, creatinine, and uric acid levels may be lower than with Levodopa alone. False-positive results may occur when urine ketone test strips are used. False-negative results may occur when glucose oxidase methods are used for glycosuria.
How should Pardopa-275 be stored?
Below 30°C, out of reach of children.
Is Pardopa-275 compatible with other medications?
Consult the product information for a comprehensive list of potential incompatibilities.
Is Pardopa-275 safe for use during pregnancy?
The effects of Pardopa-275 on human pregnancy are unknown. The use of Pardopa-275 in women of childbearing potential requires that the expected benefits be weighed against the risks.
Is Pardopa-275 safe for use during breastfeeding?
It is unknown whether Carbidopa is excreted in human milk. Due to the risk of serious adverse reactions in infants, a decision should be made to either discontinue breastfeeding or discontinue Pardopa-275, taking into account the importance of the medication for the mother.
Is Pardopa-275 safe for use in children?
The safety of Pardopa-275 in patients under 18 years of age has not been established, and its use is not recommended in patients under 18 years of age.
Is Pardopa-275 safe for use in elderly patients?
There is extensive experience in using this product in elderly patients.
What is the price of Pardopa-275 capsules #30?
The price of Pardopa-275 capsules #30 is ₦ 6900.00, exclusively for online orders through the Intaila mobile application