Philo Vitamin B12 sol. for inj. ampoules 2.0 ml #10
Manufacturer: Tianjin Kingyork Group Hubei Tianyao Pharma , China
Composition: cyanocobalamin (vitamin B12) 0.5 mg/ml
What is the active ingredient in Philo Vitamin B12 Injection?
Cyanocobalamin
How much cyanocobalamin is present in each ml of the solution?
500 micrograms (0.5mg)
What is the total volume of the solution in each ampoule?
2 ml
What is the presentation of the solution?
2 ml glass ampoules packaged in plastic trays, with 10 ampoules per pack.
Where and how should Philo Vitamin B12 Injection be stored?
Store in a dry place below 30°C, protected from heat and light.
What is the pharmacological classification of Philo Vitamin B12 Injection?
Vitamins.
How does cyanocobalamin work in the body?
It plays a crucial role in the formation and metabolism of purines and pyrimidines, which are essential components of DNA and RNA. It also participates in the synthesis of nucleoproteins, necessary for normal cell growth and development.
How is cyanocobalamin absorbed in the body?
It binds to intrinsic factor in the stomach and is actively absorbed in the small intestine. Absorption can also occur through passive diffusion.
Where is cyanocobalamin stored and how is it eliminated from the body?
It is stored in the liver, excreted in the bile, and undergoes enterohepatic recycling. A portion is excreted in the urine, primarily within the first 8 hours.
How is Philo Vitamin B12 Injection administered?
Intramuscularly.
What is the usual dosage for patients without neurological involvement?
250-1000 micrograms intramuscularly on alternate days for 1-2 weeks, followed by 250 micrograms weekly until blood count normalizes. Monthly maintenance doses of 1000 micrograms are recommended.
How is the dosage adjusted for patients with neurological involvement?
1000 micrograms on alternate days, continuing until improvement occurs.
What conditions is Philo Vitamin B12 Injection indicated for?
Vitamin B12 deficiencies, including: * Megaloblastic anemia * Neurological conditions such as pernicious anemia and its complications (subacute combined degeneration of the spinal cord) * Macrocytic anemias due to nutritional deficiencies * Intestinal malabsorption * Megaloblastosis * Dietary-related deficiencies * Post-gastrectomy
What are the prophylactic indications for Philo Vitamin B12 Injection?
Strict vegetarianism * Post-gastrectomy * Ileal resection * Conditions affecting the small intestine that could cause deficiency.
When should Philo Vitamin B12 Injection not be used?
Before a full diagnosis has been established, as it can mask symptoms of subacute spinal cord degeneration. * To treat megaloblastic anemia during pregnancy. * Before ruling out pernicious anemia or folic acid deficiency.
What is the primary warning regarding Philo Vitamin B12 Injection?
It must not be administered intravenously.
What are the potential side effects of Philo Vitamin B12 Injection?
Allergic reactions have been reported after injection.
What are the precautions associated with the use of Philo Vitamin B12 Injection?
It should be given prophylactically only when there is a clear indication. * Large doses (greater than 10 micrograms daily) may cause a hematological response in patients with folate deficiency. * Long-term therapy should be monitored with blood tests every 6-12 months for effectiveness and potential refractoriness. * Serum concentrations may be decreased by concurrent use of oral contraceptives. * Blood concentrations may be reduced with continuous high doses of folic acid.
Are there any known symptoms of overdosage with Philo Vitamin B12 Injection?
None reported.
What is the shelf life of Philo Vitamin B12 Injection?
36 months.
What is the NAFDAC registration number for Philo Vitamin B12 Injection?
B4-9095.
Who manufactures and markets Philo Vitamin B12 Injection?
Manufactured by Tianjin Kingyork Group Hubei Tianyao Pharm. Co., Ltd. * Marketed by A-Nwaeze Pharmaceutical Co., Ltd.
What is the price of Philo Vitamin B12 sol. for inj. ampoules 2.0 ml #10?
The price of Philo Vitamin B12 sol. for inj. ampoules 2.0 ml #10 is ₦ 875.00, exclusively for online orders through the Intaila mobile application