Ramitace tabl. #30
Manufacturer: May & Baker, Nigeria
Composition: ramipril 5.0 mg
What is Ramitace, and how does it work?
Ramitace is a brand name for ramipril, an angiotensin-converting enzyme (ACE) inhibitor. It blocks the action of angiotensin-converting enzyme, preventing the body from producing angiotensin II, a vasoconstrictor. This relaxes blood vessels, lowering blood pressure.
What are the different presentations and compositions of Ramitace?
Ramitace tablets are available in 5mg and 10mg strengths, with each pack containing 30 tablets.
How is Ramitace absorbed and metabolized in the body?
Ramipril is a prodrug activated in the liver to ramiprilat. It's rapidly absorbed, with peak plasma concentrations within an hour. Ramiprilat peaks in 2-4 hours. About 60% is eliminated in urine, 40% in feces.
What is the half-life of Ramitace and its active metabolite, ramiprilat?
Ramipril has a half-life of 9-18 hours. Ramiprilat has a prolonged half-life of 50 hours.
What are the indications and uses of Ramitace?
- Reducing cardiovascular event risk in patients with coronary artery disease, stroke, peripheral vascular disease, or diabetes with other risk factors. * Treating hypertension, alone or in combination with other medications. * Treating stable heart failure patients after a myocardial infarction.
What are the contraindications for using Ramitace?
- Pregnancy (categories C in the first trimester, D in the second and third) * Lactation * Children * Hypersensitivity to ramipril or ACE inhibitors * History of angioedema with ACE inhibitors
What are the potential drug interactions with Ramitace?
- NSAIDs: May attenuate antihypertensive effect and increase renal impairment risk. * Diuretics: Can cause excessive blood pressure reduction. * Lithium: Increases lithium levels and toxicity risk. * Potassium-sparing diuretics: Increases hyperkalemia risk. * Gold: Rarely causes nitritoid reactions.
What are the common side effects of Ramitace?
- Cardiovascular: Hypotension, dizziness, syncope, palpitations, tachycardia * Renal: Impaired function, proteinuria * Hematologic: Neutropenia * Metabolic: Hyperkalemia * Gastrointestinal: Nausea, vomiting, diarrhea, abdominal pain, constipation * Dermatologic: Rash, pruritus, angioedema * Other: Cough, fatigue, headache
What is the recommended dosage and administration of Ramitace?
The usual starting dose is 2.5mg once daily, gradually increased to achieve desired effect. Take with half a glass of liquid during or after meals.
What is the role of Ramitace in managing hypertension in elderly patients?
Elderly patients may be more sensitive to Ramitace, leading to higher peak ramiprilat levels. Careful monitoring of blood pressure and renal function is crucial.
How is Ramitace overdose managed?
The main concern is severe hypotension. Management includes supportive measures like infusion of normal saline solution.
What should I be aware of regarding Ramitace in relation to pregnancy and lactation?
Ramitace is contraindicated in pregnancy due to potential harm to the fetus. It's not recommended for breastfeeding mothers because small amounts can pass into breast milk.
What are the storage conditions for Ramitace tablets?
Store below 30°C in a cool, dry place. Keep out of reach of children.
What are the general precautions and warnings associated with Ramitace use?
- Monitor renal function in patients with impaired renal function. * Be aware of potential hypotension, especially at the start of treatment or with diuretics. * Monitor potassium levels in patients taking potassium-sparing diuretics or potassium supplements. * Monitor liver function in patients with impaired liver function. * Inform surgeons/anesthesiologists of Ramitace use before surgery. * Stop Ramitace and seek immediate medical attention if angioedema occurs. * Be aware of potential dry, persistent cough as a common side effect.
What is the price of Ramitace tabl. #30?
The price of Ramitace tabl. #30 is ₦ 1750.00, exclusively for online orders through the Intaila mobile application