Tamsulosin-XL 400 mcg capsules #30
Manufacturer: Globela Pharma, India
Composition: tamsulosin 0.4 mg
What is the generic name of Tamsulosin-XL?
Tamsulosin Hydrochloride
What is the indication for Tamsulosin-XL?
Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH)
What is the recommended dosage of Tamsulosin-XL?
The text does not specify a recommended dosage.
What is the mechanism of action of Tamsulosin-XL?
Tamsulosin selectively and competitively binds to the postsynaptic alpha-adrenoceptors, particularly subtypes α1A and α1D. This results in relaxation of the prostatic and urethral smooth muscle, thereby improving voiding symptoms and increasing maximum urinary flow rate.
What are the pharmacodynamic effects of Tamsulosin-XL?
Tamsulosin improves both storage and voiding symptoms associated with BPH. It relieves obstruction by relaxing the smooth muscle in the prostate and urethra, leading to increased urine flow. It also helps with bladder instability.
What are the pharmacokinetic properties of Tamsulosin-XL?
Tamsulosin is absorbed from the intestine and is almost completely bioavailable. It has a low first-pass effect and is slowly metabolized. It is highly bound to plasma proteins and has a small volume of distribution. Elimination occurs primarily through urine.
What are the contraindications for Tamsulosin-XL?
Hypersensitivity to tamsulosin, including drug-induced angioedema, or to any of the excipients. Severe hepatic insufficiency. History of orthostatic hypotension.
What are the precautions associated with Tamsulosin-XL?
Patients should be examined to rule out other conditions that might cause similar symptoms before starting treatment. Patients should be monitored for orthostatic hypotension. Tamsulosin should be used cautiously in patients with severe renal impairment. Patients should be informed about the risk of Intraoperative Floppy Iris Syndrome (IFIS) during cataract surgery. Tamsulosin should be used with caution in combination with strong and moderate inhibitors of CYP3A4.
What are the potential drug interactions with Tamsulosin-XL?
Concomitant cimetidine increases tamsulosin plasma levels. Furosemide may decrease tamsulosin levels. Strong CYP3A4 inhibitors may increase exposure to tamsulosin. No significant interactions are observed with atenolol, enalapril, nifedipine, or theophylline.
What are the potential side effects of Tamsulosin-XL?
Major Side Effects: Angioedema, Intraoperative Floppy Iris Syndrome (IFIS), Ejaculation disorders (retrograde ejaculation and ejaculation failure). Minor Side Effects: Abnormal ejaculation, back pain, headache, nasal congestion, dizziness, orthostatic hypotension. Others: See detailed list in the provided text.
What is the treatment for Tamsulosin-XL overdose?
In case of acute hypotension, cardiovascular support should be provided. The patient should be laid down to restore blood pressure. Volume expanders and vasopressors may be used. Renal function should be monitored and general supportive measures applied.
What are the packaging and storage conditions for Tamsulosin-XL?
10 capsules per blister pack, 3 blister packs per carton. Store below 30°C, protected from light.
What is the name and address of the manufacturer and marketing authorization holder?
Manufacturer: Globela Pharma Pvt. Ltd., India. Marketing Authorization Holder: Dezubik Pharmacy Ltd., Nigeria
Can Tamsulosin-XL be used during pregnancy or lactation?
No, Tamsulosin is not indicated for use in women.
Are there any specific considerations for pediatric patients regarding Tamsulosin-XL?
A double-blind, randomized, placebo-controlled study was performed in children (2 to 16 years old) with neuropathic bladder, but the text does not provide further information on the specific dosage or safety for this population.
What is the price of Tamsulosin-XL 400 mcg capsules #30?
The price of Tamsulosin-XL 400 mcg capsules #30 is ₦ 3750.00, exclusively for online orders through the Intaila mobile application