Torsinex-10 tabl. #30
Manufacturer: Micro Labs, India
Composition: torsemide 10.0 mg
What is the active ingredient in Torsinex-10?
Torsemide USP 10 mg.
How does Torsemide work as a diuretic?
Torsemide inhibits the Na-K-2Cl symporter in the thick ascending limb of the nephron, blocking salt transport and leading to increased excretion of sodium, chloride, and water.
Does Torsemide affect glomerular filtration rate or renal plasma flow?
No, it does not significantly alter these parameters.
How does Torsemide affect the kidney's ability to excrete dilute urine?
It markedly impairs this ability due to its action on the thick ascending limb, which is part of the diluting segment.
What is the mechanism of Torsemide's vascular effect?
It acutely increases systemic venous capacitance, thereby decreasing left ventricular filling pressure.
What is the bioavailability of Torsemide?
Approximately 80%.
Where does Torsemide reach its peak serum concentration (Cmax) after oral administration?
Within 1 hour.
Does food intake affect Torsemide's absorption?
It delays the time to Cmax by about 30 minutes, but overall bioavailability and diuretic activity remain unchanged.
How is Torsemide eliminated from the body?
Primarily by hepatic metabolism (approximately 80%) and excretion into the urine (approximately 20% in patients with normal renal function).
What is the major metabolite of Torsemide in humans?
The carboxylic acid derivative, which is biologically inactive.
To what extent is Torsemide bound to plasma protein?
Extensively, exceeding 99%.
What conditions is Torsinex-10 indicated for?
Treatment of edema associated with congestive heart failure, renal disease, hepatic disease, and chronic renal failure. It is also indicated for the treatment of hypertension alone or in combination with other antihypertensive agents.
When is Torsinex-10 contraindicated?
Patients with known hypersensitivity to torsemide or sulfonylureas, and patients who are anuric.
What are the most common side effects of Torsemide?
Dizziness, headache, nausea, weakness, vomiting, hyperglycemia, excessive urination, hyperuricemia, hypokalemia, excessive thirst, hypovolemia, impotence, esophageal hemorrhage, and dyspepsia.
How should Torsinex-10 be used in patients with hepatic disease with cirrhosis and ascites?
With caution, as sudden alterations in fluid and electrolyte balance may precipitate hepatic coma.
What ototoxicity concerns are associated with Torsemide?
Tinnitus and hearing loss (usually reversible) have been observed after rapid intravenous injection of other loop diuretics and also after oral Torsemide.
What should be monitored in patients receiving Torsemide?
For clinical evidence of electrolyte imbalance, hypovolemia, or prerenal azotemia.
How does Torsemide interact with high doses of salicylates?
Concomitant administration may lead to salicylate toxicity.
What is the effect of indomethacin on Torsemide's natriuretic effect?
It partially inhibits it.
How does probenecid affect Torsemide's diuretic activity?
It reduces secretion of Torsemide into the proximal tubule, decreasing its diuretic activity.
What is the concern regarding co-administration of lithium and diuretics?
It carries a high risk of lithium toxicity.
What is the usual initial dose of Torsemide for congestive heart failure?
10 mg or 20 mg once daily.
How should the dose be adjusted if the initial dose is inadequate?
Titrate upward by approximately doubling until the desired diuretic response is obtained.
What is the usual initial dose of Torsemide for chronic renal failure?
20 mg once daily.
What is the usual initial dose of Torsemide for hepatic cirrhosis?
5 mg or 10 mg once daily, administered together with an aldosterone antagonist or a potassium-sparing diuretic.
What is the usual initial dose of Torsemide for hypertension?
5 mg once daily.
What are the signs and symptoms of Torsemide overdosage?
Dehydration, hypovolemia, hypotension, hyponatremia, hypokalemia, hypochloremic alkalosis, and hemoconcentration.
How is Torsemide overdosage treated?
With fluid and electrolyte replacement.
What are the storage conditions for Torsinex-10?
Store below 30°C. Keep out of reach of children.
What is the price of Torsinex-10 tabl. #30?
The price of Torsinex-10 tabl. #30 is ₦ 3148.75, exclusively for online orders through the Intaila mobile application